Anticoagulants
- Name
- Anticoagulants
- Accession Number
- DBCAT000007 (DBCAT003243)
- Description
Agents that prevent clotting.
- Drugs
Drug Drug Description (R)-warfarin Warfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared by different pathways. S-warfarin is 2-5 times more potent than the R-isomer in... (S)-Warfarin Warfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared by different pathways. S-warfarin is 2-5 times more potent than the R-isomer in... 4-hydroxycoumarin Not Available Abciximab A monoclonal anti-glycoprotein IIb/IIIa receptor antibody used to prevent thrombosis during percutaneous coronary intervention. Acenocoumarol An anticoagulant drug used in the prevention of thromboembolic diseases in infarction and transient ischemic attacks, as well as management of deep vein thrombosis and myocardial infarction. Alteplase A recombinant form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli. Amediplase Investigated for use/treatment in myocardial infarction and thrombosis. Ancrod An anticoagulant purified from the venom of the Malayan pit viper that functions by inactivating circulating plasma fibrinogen. Not currently approved for use or marketed in any country. Anistreplase A form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli. Antithrombin Alfa A recombinant antithrombin used to treat peri-operative and peripartum thromboembolic events in hereditary antithrombin deficiency. Antithrombin III human An alpha-2-glycoprotein used to prevent thromboembolisms in patients with hereditary antithrombin III deficiency. Apadamtase alfa A recombinant human ADAMTS13 for enzyme replacement therapy in patients with congenital thrombotic thrombocytopenic purpura. Apafant Apafant is a small molecule drug. The usage of the INN stem '-pafant' in the name indicates that Apafant is a platelet-activating factor antagonist. Apafant has a monoisotopic molecular weight... Apixaban An anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery. Ardeparin For prevention of deep vein thrombosis, which may result in pulmonary embolism, following knee surgery. Argatroban A synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use. Astaxanthin Investigated for use/treatment in eye disorders/infections, cancer/tumors (unspecified), and asthma. Bemiparin An ultra-low molecular weight heparin (ultra-LMWH) used to prevent thromboembolism following surgery and extracorporeal clotting during dialysis. Benzarone Benzarone is a small molecule drug. Benzarone has a monoisotopic molecular weight of 266.09 Da. Beraprost For the treatment of pulmonary hypertension. Betrixaban A Factor Xa inhibitor used for prophylaxis of venous thromboembolism in hospitalized patients. Bivalirudin A direct thrombin inhibitor used to treat heparin-induced thrombocytopenia and to prevent thrombosis during percutaneous coronary intervention. Brinase Not Annotated Cangrelor A P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST). Certoparin A low molecular weight heparin (LMWH) used to prevent blood clots, specifically deep vein thrombosis. Cinnamic acid Not Annotated Clorindione Clorindione is a vitamin K antagonist, which may be useful to decrease prothrombin levels in humans. Coumarin Not Available CTB001 CTB001 is an anti-claudin 18.2 autologous chimeric antigen receptor (CAR) T-cell therapy under investigation for the treatment of gastric cancers. Dabigatran Dabigatran is the active form of the orally bioavailable prodrug dabigatran etexilate. Dabigatran etexilate An anticoagulant used for the prevention of venous thromboembolic events or stroke in patients with recent elective hip or knee replacement surgery and atrial fibrillation. Dalteparin A low molecular weight heparin used for the prophylaxis of thrombotic events in certain patients and prevent acute cardiac ischemic events in patients with unstable angina and non-Q-wave myocardial infarction. Danaparoid A heparinoid with anticoagulant and antithrombotic activities used for the treatment of acute episode of Heparin-Induced Thrombocytopenia (HIT), and for prophylaxis in patients with a history of HIT. Darexaban Darexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others. Defibrotide A mixture of single-stranded oligonucleotides used in the treatment of severe hepatic veno-occlusive disease with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation. Dermatan sulfate A medication indicated to prevent deep vein thrombosis. Desirudin Indicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery. Desmoteplase Investigated for use/treatment in cerebral ischemia and strokes. Dextran A low molecular weight dextran used as an adjunctive treatment of shock or impending shock due to hemorrhage, burns, surgery or other trauma, as well as the prophylaxis of venous thrombosis and pulmonary embolism during high-risk medical procedures. Dicoumarol For decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis. Diphenadione Not Annotated Dipyridamole A phosphodiesterase inhibitor used to prevent postoperative thromboembolic events. Ditazole Ditazole is a non-steroidal anti-inflammatory drug (NSAID). Ditazole's analgesic and antipyretic effects are similar to phenylbutazone. Additionally, ditazole is a platelet aggregation inhibitor marketed in Spain and Portugal with trade... Dociparstat sodium Not Available Drotrecogin alfa A form of recombinant activated human protein C used to reduce mortality in patients with severe sepsis by inhibiting coagulation Factors V and VIII. Edetate calcium disodium anhydrous A chelating agent used to treat lead poisoning. Edetic acid A chelating agent used to treat mercury and lead toxicity and some blood transfusion dependent anemias. Edoxaban A novel oral anticoagulant used for reducing the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF). Efegatran Efegatran is a small molecule drug. Efegatran has a monoisotopic molecular weight of 416.25 Da. Enoxaparin A low molecular weight heparin used for the prophylaxis of deep vein thrombosis and ischemic complications of unstable angina and non-Q-wave myocardial infarction. Epoprostenol A vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure. Ethyl biscoumacetate Ethyl biscoumacetate is a courmarin that is used as an anticoagulant. It has actions similar to those of Warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226) Ferulic acid Not Available Fibrinolysin Fibrinolysin assists with the healing of minor burns, superficial wounds, ulcers, surgical wounds, and superficial hematomas. Fluindione Fluindione is under investigation for the treatment of Venous Thrombosis, Pulmonary Embolism, Permanent Atrial Fibrillation, and Anticoagulating Treatment on a Duration at Least 12-month-old Superior. Fluindione has been investigated for... Fondaparinux An anticoagulant used to prevent venous thromboembolism, to treat deep vein thrombosis, and to improve survival following myocardial infarction. Gabexate A protease inhibitor indicated in the treatment of acute pancreatitis. GW-813893 Not Available Heparin An anticoagulant indicated for thromboprophylaxis and to treat thrombosis associated with a variety of conditions such as pulmonary embolism and atrial fibrillation. Idraparinux Investigated for use/treatment in thrombosis, venous thromboembolism, strokes, heart disease, and atrial fibrillation. Inogatran Inogatran is a small molecule drug. Inogatran has a monoisotopic molecular weight of 438.3 Da. Isbogrel Isbogrel is a small molecule drug. Isbogrel has a monoisotopic molecular weight of 281.14 Da. Lamifiban Lamifiban is a small molecule drug. The usage of the INN stem '-fiban' in the name indicates that Lamifiban is a fibrinogen receptor antagonist (glycoprotein IIb/IIIa receptor antagonist). Lamifiban has... Lepirudin A protein-based direct thrombin inhibitor used as an anticoagulant in patients with heparin-induced thrombocytopenia. Letaxaban Letaxaban has been used in trials studying the treatment and prevention of Venous Thromboembolism and Acute Coronary Syndrome. Limaprost An oral prostaglandin E1 analogue used to improve symptoms associated with thromboangiitis obliterans, acquired lumbar spinal canal stenosis, and other ischemic conditions. Linotroban Linotroban is a small molecule drug. Linotroban has a monoisotopic molecular weight of 341.04 Da. Melagatran Not Annotated Monteplase Monteplase has been used in trials studying the treatment of Pulmonary Embolism. Moxicoumone Moxicoumone is a small molecule drug. Moxicoumone has a monoisotopic molecular weight of 418.21 Da. Nadroparin A low molecular weight heparin used for the prophylaxis of thrombotic events and deep vein thrombosis, and prevent unstable angina and non-Q-wave myocardial infarction. Nafamostat Used as an anticoagulant in patients with disseminative blood vessel coagulation, hemorrhagic lesions, and hemorrhagic tendencies. It prevents blood clot formation during extracorporeal circulation in patients undergoing continuous renal replacement... Otamixaban Investigated for use/treatment in thrombosis. Pamiteplase Not Annotated Parnaparin A low molecular weight heparin (LMWH) used to prevent blood clots, specifically deep vein thrombosis. Pentosan polysulfate A sulfated pentosyl polysaccharide used to treat bladder pain and discomfort due to interstitial cystitis. Phenindione For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis. Phenprocoumon An anticoagulant drug used for the prevention of thrombosis. Plasminogen Plasma-derived human plasminogen administered intravenously to treat type 1 plasminogen deficiency (hypoplasminogenemia). Plumbagin Plumbagin is a compound investigated for its anticancer activity. It has been found that it inactivates the Akt/NF-kB, MMP-9 and VEGF pathways. Prasugrel A P2Y12 platelet inhibitor used to reduce risk of thrombotic cardiovascular events in unstable angina or non-ST-elevation myocardial infarction (NSTEMI), and in patients with STEMI when managed with either primary or delayed PCI. Protein C A medication used to treat protein C deficiency leading to purpura fulminans or coumarin-induced skin necrosis. Protein S human A medication used for emergency reversal of coagulation factor deficiency in vitamin K antagonist therapy. Protocatechualdehyde Also known as protocatechuic aldehyde, protocatechualdehyde is a naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of the herb S. miltiorrhiza . Protocatechualdehyde... Reteplase A purified form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli. Reviparin By the FDA, reviparin is indicated for the treatment of deep vein which may lead to pulmonary embolism in pediatric patients. It is also indicated for the long-term treatment of... Rivaroxaban A factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations. Saruplase Not Annotated Semuloparin Investigated for use/treatment in thrombosis. Sodium citrate An ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures. SR-123781A Investigated for use/treatment in cardiovascular disorders, thrombosis, and venous thromboembolism. Streptokinase A purified fibrinolytic bacterial protein used to breakdown thrombosis in myocardial infarction, pulmonary embolism, and venous thromboembolism. Sulodexide A drug used to treat chronic venous ulcers in the legs. Sulotroban Sulotroban is a small molecule drug. Sulotroban has a monoisotopic molecular weight of 335.08 Da. Tanshinone I Not Annotated Tenecteplase A modified form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction, pulmonary emboli, and ischemic stroke. Ticagrelor A P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death. Tinzaparin A low molecular weight heparin used for the treatment of acute symptomatic deep vein thrombosis with or without pulmonary embolism when administered in conjunction with warfarin. Tioclomarol Not Annotated Tocopherylquinone Not Annotated Triflusal A medication related to acetylsalicylic acid with antithrombotic effects used in the treatment of thromboembolic diseases. Troxerutin Troxerutin has been used in trials studying the treatment of Chronic Venous Insufficiency. Urokinase A low molecular weight form of human urokinase used to treat pulmonary embolism and myocardial infarction as well as to clear IV lines. Vapiprost Vapiprost is a small molecule drug. Vapiprost has a monoisotopic molecular weight of 477.29 Da. Vorapaxar A platelet aggregation inhibitor used to reduce thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or peripheral arterial disease (PAD). Warfarin A vitamin K antagonist used to treat venous thromboembolism, pulmonary embolism, thromboembolism with atrial fibrillation, thromboembolism with cardiac valve replacement, and thromboembolic events post myocardial infarction. Ximelagatran For the treatment of acute deep vein thrombosis. - Drugs & Drug Targets