Boron

Identification

Generic Name

Boron

DrugBank Accession Number

DB11203

Background

Boron (B) is a chemical element with an atomic number 5 that belongs in the Period 2 and Group 13 in the periodic table. It is a low-abundant metalloid that is a poor electrical conductor at room temperature. Natural boron exists in 2 stable isotopes however pure boron is hard to prepare due to contamination by different elements. It is also found for applications including ceramics, high-hardness or abrasive compounds, metal coatings, detergents, bleaching agents, insecticides, semiconductors, magnets, wood preservatives, and an additive in glass fibers of boron-containing fiberglass for insulation and structural materials. Boric acid contains antiseptic, antifungal, and antiviral properties thus it is used as a water clarifier in swimming pool water treatment. There are few pharmaceutical agents that contain a boron molecule in their structures, such as Tavaborole and Bortezomib.

Type

Small Molecule

Groups

Experimental

Structure

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MOLSDFPDBSMILESInChI

Similar Structures

Structure for Boron (DB11203)

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Weight

Average: 10.81
Monoisotopic: 11.009305

Chemical Formula

B

Synonyms

• Bor
• Boracium
• Bore
• Boro

Pharmacology

Indication

Not Available

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Associated Conditions

• Osteoporosis

Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Not Available

Food Interactions

Not Available

Products

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Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Calcemin	Boron (50 ug/1) + Previtamin D(3) (0.75 mg/1) + Zinc (2 mg/1)	Tablet, film coated	Oral	Bayer Healthcare Llc.	2016-04-01	Not applicable
Calcemin Silver	Boron (2.6 mg/1) + Magnesium oxide (40 mg/1) + Zinc oxide (7.5 mg/1)	Tablet, film coated	Oral	Bayer Healthcare Llc.	2016-04-01	Not applicable
MENOPACE KAPSUL, 30 ADET	Boron (2 mg) + Aminobenzoic acid (30 mg) + Ascorbic acid (45 mg) + Biotin (30 mcg) + Chromium picolinate (50 mcg) + Copper (1 mg) + Cyanocobalamin (9 mcg) + Folic acid (400 mcg) + Iodine (225 mcg) + Iron (12 mg) + Magnesium (100 mg) + Manganese (2 mg) + Niacin (20 mg) + Pantothenic acid (30 mg) + Pyridoxine (40 mg) + Riboflavin (5 mg) + Selenium (100 mcg) + Thiamine (10 mg) + Vitamin A (750 mcg) + Vitamin D (2.5 mcg) + Vitamin E (30 mg) + Zinc (15 mg)	Capsule	Oral	NOBEL İLAÇ SAN. VE TİC. A.Ş.	2020-08-14	2020-05-28

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Calcium Folic Acid Plus D Chewable	Boron (250 ug/1) + Calcium carbonate (1342 mg/1) + Cholecalciferol (300 [iU]/1) + Cyanocobalamin (125 ug/1) + Folic acid (1 mg/1) + Magnesium (50 mg/1) + Pyridoxine (10 mg/1)	Wafer	Oral	Acella Pharmaceuticals, LLC	2009-03-20	2022-08-02
Foliflex	Boron (25 ug/1) + Ascorbic acid (250 mg/1) + Biotin (100 ug/1) + Calcium carbonate (75 mg/1) + Cholecalciferol (13.75 ug/1) + Chromium nicotinate (37.5 ug/1) + Cupric oxide (1 mg/1) + Cyanocobalamin (13 ug/1) + DL-alpha tocopheryl acetate (45 mg/1) + Ferrous fumarate (9 mg/1) + Folic acid (500 ug/1) + Magnesium oxide (37.5 mg/1) + Manganese sulfate (0.75 mg/1) + Molybdenum (25 ug/1) + Nicotinamide (22.5 mg/1) + Pantothenic acid (15 mg/1) + Potassium Iodide (25 ug/1) + Potassium chloride (24.5 mg/1) + Pyridoxine hydrochloride (6 mg/1) + Riboflavin (3.35 mg/1) + Selenium (30 ug/1) + Thiamine mononitrate (3.25 mg/1) + Vitamin A acetate (1500 ug/1) + Zinc oxide (15 mg/1)	Tablet	Oral	PureTek Corporation	2021-10-25	Not applicable
Folitin-Z	Boron (25 ug/1) + Ascorbic acid (250 mg/1) + Biotin (100 ug/1) + Calcium carbonate (75 mg/1) + Cholecalciferol (13.75 ug/1) + Chromium nicotinate (37.5 ug/1) + Cupric oxide (1 mg/1) + Cyanocobalamin (13 ug/1) + DL-alpha tocopheryl acetate (45 mg/1) + Ferrous fumarate (9 mg/1) + Folic acid (500 ug/1) + Magnesium oxide (37.5 mg/1) + Manganese sulfate (0.75 mg/1) + Molybdenum (25 ug/1) + Nicotinamide (22.5 mg/1) + Pantothenic acid (15 mg/1) + Potassium Iodide (25 ug/1) + Potassium chloride (24.5 mg/1) + Pyridoxine hydrochloride (6 mg/1) + Riboflavin (3.35 mg/1) + Selenium (30 ug/1) + Thiamine mononitrate (3.25 mg/1) + Vitamin A acetate (1500 ug/1) + Zinc oxide (15 mg/1)	Tablet	Oral	PureTek Corporation	2021-02-11	Not applicable
Neonatal Plus Vitamin	Boron (0.2 mg/1) + Ascorbic acid (20 mg/1) + Calcium (200 mg/1) + Cholecalciferol (10 ug/1) + Citrus bioflavonoids (2 mg/1) + Copper (2 mg/1) + Cyanocobalamin (12 ug/1) + Ferrous fumarate (27 mg/1) + Folic acid (1000 ug/1) + Inositol (5 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (3 mg/1) + Thiamine chloride (1.84 mg/1) + Vitamin A (1200 ug/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (9.2 mg/1)	Tablet	Oral	Neomed Pharmaceutical	2018-07-31	Not applicable
Prenate Chewable	Boron (250 ug/1) + Bilberry (25 mg/1) + Biotin (280 ug/1) + Calcium carbonate (500 mg/1) + Cholecalciferol (300 [iU]/1) + Cyanocobalamin (125 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (50 mg/1) + Pyridoxine hydrochloride (10 mg/1)	Tablet, chewable	Oral	Avion Pharmaceuticals, Llc	2013-01-16	Not applicable
Ribotin-E	Boron (25 ug/1) + Ascorbic acid (250 mg/1) + Biotin (100 ug/1) + Calcium carbonate (75 mg/1) + Cholecalciferol (13.75 ug/1) + Chromium nicotinate (37.5 ug/1) + Cupric oxide (1 mg/1) + Cyanocobalamin (13 ug/1) + DL-alpha tocopheryl acetate (45 mg/1) + Ferrous fumarate (9 mg/1) + Folic acid (500 ug/1) + Magnesium oxide (37.5 mg/1) + Manganese sulfate (0.75 mg/1) + Molybdenum (25 ug/1) + Nicotinamide (22.5 mg/1) + Pantothenic acid (15 mg/1) + Potassium Iodide (25 ug/1) + Potassium chloride (24.5 mg/1) + Pyridoxine hydrochloride (6 mg/1) + Riboflavin (3.35 mg/1) + Selenium (30 ug/1) + Thiamine mononitrate (3.25 mg/1) + Vitamin A acetate (1500 ug/1) + Zinc oxide (15 mg/1)	Tablet	Oral	PureTek Corporation	2021-02-11	Not applicable
Zintrexyl-C	Boron (25 ug/1) + Ascorbic acid (250 mg/1) + Biotin (100 ug/1) + Calcium carbonate (75 mg/1) + Cholecalciferol (13.75 ug/1) + Chromium nicotinate (37.5 ug/1) + Cupric oxide (1 mg/1) + Cyanocobalamin (13 ug/1) + DL-alpha tocopheryl acetate (45 mg/1) + Ferrous fumarate (9 mg/1) + Folic acid (500 ug/1) + Magnesium oxide (37.5 mg/1) + Manganese sulfate (0.75 mg/1) + Molybdenum (25 ug/1) + Nicotinamide (22.5 mg/1) + Pantothenic acid (15 mg/1) + Potassium Iodide (25 ug/1) + Potassium chloride (24.5 mg/1) + Pyridoxine hydrochloride (6 mg/1) + Riboflavin (3.35 mg/1) + Selenium (30 ug/1) + Thiamine mononitrate (3.25 mg/1) + Vitamin A acetate (1500 ug/1) + Zinc oxide (15 mg/1)	Tablet	Oral	PureTek Corporation	2021-02-11	Not applicable

Categories

Drug Categories

• Diet, Food, and Nutrition
• Elements
• Food
• Metalloids
• Micronutrients
• Physiological Phenomena
• Trace Elements

Chemical TaxonomyProvided by Classyfire

Description

This compound belongs to the class of inorganic compounds known as homogeneous metalloid compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a metalloid atom.

Kingdom

Inorganic compounds

Super Class

Homogeneous metal compounds

Class

Homogeneous metalloid compounds

Sub Class

Not Available

Direct Parent

Homogeneous metalloid compounds

Alternative Parents

Not Available

Substituents

Homogeneous metalloid

Molecular Framework

Not Available

External Descriptors

boron group element atom, nonmetal atom (CHEBI:27560)

Affected organisms

Not Available

Chemical Identifiers

UNII

N9E3X5056Q

CAS number

7440-42-8

InChI Key

ZOXJGFHDIHLPTG-UHFFFAOYSA-N

InChI

InChI=1S/B

IUPAC Name

boranylidyne

SMILES

[B]

References

General References

Not Available

External Links

PubChem Compound

5462311

PubChem Substance

347827941

ChemSpider

4575371

RxNav

1705

ChEBI

27560

Wikipedia

Boron

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
3	Completed	Treatment	Radiodermatitis	1
2	Active Not Recruiting	Treatment	Advanced Malignant Solid Tumor / Recurrent Malignant Solid Neoplasm	1
1	Terminated	Treatment	Brain and Central Nervous System Tumors	1
1	Unknown Status	Treatment	Diabetic Foot Ulcers (DFUs)	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Capsule	Oral
Tablet, film coated	Oral
Wafer	Oral
Tablet	Oral
Tablet, chewable	Oral

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
logP	0.33	Chemaxon
Physiological Charge	0	Chemaxon
Hydrogen Acceptor Count	0	Chemaxon
Hydrogen Donor Count	0	Chemaxon
Polar Surface Area	0 Å2	Chemaxon
Rotatable Bond Count	0	Chemaxon
Refractivity	0 m3·mol-1	Chemaxon
Polarizability	1.78 Å3	Chemaxon
Number of Rings	0	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	Yes	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	Not Available

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Drug created at December 03, 2015 16:51 / Updated at September 28, 2021 21:54