Large neutral amino acids transporter small subunit 1

BE0000222ProteinHumansSLC7A5

Forms a heterodimer with SLC3A2 that functions as a sodium-independent transporter for large neutral amino acids (PubMed:9751058, PubMed:10049700, PubMed:11557028, PubMed:10574970, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:15769744, PubMed:18262359, PubMed:25998567, PubMed:30867591). It is acted on by 23 drugs in DrugBank.

Gene name
SLC7A5
UniProtKB entry
Q01650Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
507 residues · 55,010 Da
Also known as
4F2 LC · 4F2 light chain · 4F2LC · CD98 light chain · CD98LC

Resolves to

Protein
UniProtQ01650UniProt nameLAT1_HUMAN
Gene
HGNCHGNC:11063NCBI Gene8140GenBank3639058GeneCardsSLC7A5
Pharmacology
KEGGhsa:8140
Structure
PDB6IRSPDB6IRTPDB6JMQ
Drugs

What you can answer from here — as of September 07, 2019

23DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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40GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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81+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Large neutral amino acids transporter small subunit 1, how selective are they, and which programs against it are still in active trials?

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