This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Ascorbyl phosphate
DrugBank Accession Number
DB11352
Background

Ascorbyl phosphate is a synthetic form of Vitamin C and is found in different salt forms such as magnesium ascorbyl phosphate and sodium ascorbyl phosphate. These salts are present in cosmetic products at concentrations ranging from 0.001 % to 3% 1. As vitamin C is susceptible to breakdown of compound and discoloration in cosmetic formulations, ascorbyl phosphate, along with other Vitamin C derivatives, acts as an active and stable precursor of vitamin C that is readily absorbed into the skin with a hydrating effect on the skin 2. While ascorbyl phosphate salts provide a constant delivery of vitamin C into the skin, they also mediate an antioxidant action to act as a free radical scavenger and increases collagen production in vitro 2.

Type
Small Molecule
Groups
Approved
Synonyms
Not Available

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
DoxycyclineThe therapeutic efficacy of Doxycycline can be decreased when used in combination with Ascorbyl phosphate.
ErythromycinThe therapeutic efficacy of Erythromycin can be decreased when used in combination with Ascorbyl phosphate.
KanamycinThe therapeutic efficacy of Kanamycin can be decreased when used in combination with Ascorbyl phosphate.
LincomycinThe therapeutic efficacy of Lincomycin can be decreased when used in combination with Ascorbyl phosphate.
StreptomycinThe therapeutic efficacy of Streptomycin can be decreased when used in combination with Ascorbyl phosphate.
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Food Interactions
No interactions found.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Magnesium ascorbyl phosphate0R822556M5113170-55-1PBSRSWFGYPZDAU-FFIPNUABSA-H
Active Moieties
NameKindUNIICASInChI Key
Ascorbic acidunknownPQ6CK8PD0R50-81-7CIWBSHSKHKDKBQ-JLAZNSOCSA-N
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
ELCURE C SerumLiquid500 mg/50mLTopicalElcure Co., Ltd.2012-12-312017-04-20US flag
ELCURE Vitamin C SerumLiquid1.5 g/50mLTopicalElcure Co., Ltd.2011-08-222017-04-20US flag
K Oxiderm OP Post Procedure skin care bruiseCream0.5 g/100mLTopicalEzekielcosmetic Co., Ltd2017-08-17Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Le-Blen Vitamin C SerumMagnesium ascorbyl phosphate (0.57 g/56.7g) + Sodium hyaluronate (2.84 g/56.7g)LotionTopicalLeBlen Beauty Inc2018-04-24Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ELCURE C SerumMagnesium ascorbyl phosphate (500 mg/50mL)LiquidTopicalElcure Co., Ltd.2012-12-312017-04-20US flag
ELCURE Vitamin C SerumMagnesium ascorbyl phosphate (1.5 g/50mL)LiquidTopicalElcure Co., Ltd.2011-08-222017-04-20US flag
K Oxiderm OP Post Procedure skin care bruiseMagnesium ascorbyl phosphate (0.5 g/100mL)CreamTopicalEzekielcosmetic Co., Ltd2017-08-17Not applicableUS flag
Le-Blen Vitamin C SerumMagnesium ascorbyl phosphate (0.57 g/56.7g) + Sodium hyaluronate (2.84 g/56.7g)LotionTopicalLeBlen Beauty Inc2018-04-24Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
Not Available
CAS number
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

References

General References
  1. Klock J, Ikeno H, Ohmori K, Nishikawa T, Vollhardt J, Schehlmann V: Sodium ascorbyl phosphate shows in vitro and in vivo efficacy in the prevention and treatment of acne vulgaris. Int J Cosmet Sci. 2005 Jun;27(3):171-6. doi: 10.1111/j.1467-2494.2005.00263.x. [Article]
  2. Telang PS: Vitamin C in dermatology. Indian Dermatol Online J. 2013 Apr;4(2):143-6. doi: 10.4103/2229-5178.110593. [Article]
PubChem Substance
347911194
RxNav
1370605

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LiquidTopical500 mg/50mL
LiquidTopical1.5 g/50mL
CreamTopical0.5 g/100mL
LotionTopical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at December 03, 2015 16:52 / Updated at June 12, 2020 16:53