Calcium/calmodulin-dependent protein kinase type II subunit alpha

BE0004076ProteinHumansCAMK2A

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). It is acted on by 5 drugs in DrugBank.

Gene name
CAMK2A
UniProtKB entry
Q9UQM7Swiss-Prot
Cellular location
Synapse
Residues / weight
478 residues · 54,087 Da
Also known as
2.7.11.17 · CaM kinase II subunit alpha · CaMK-II subunit alpha · CAMKA · KIAA0968

Resolves to

Protein
UniProtQ9UQM7UniProt nameKCC2A_HUMAN
Gene
HGNCHGNC:1460NCBI Gene815GenBank4836793GeneCardsCAMK2A
Pharmacology
KEGGhsa:815
Structure
PDB2VZ6PDB3SOAPDB5IG3
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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21GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calcium/calmodulin-dependent protein kinase type II subunit alpha, how selective are they, and which programs against it are still in active trials?

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