Thiostrepton

DB11467InvestigationalVet approvedSmall molecule

Thiostrepton is a natural cyclic oligopeptide antibiotic, derived from several strains of streptomycetes including Streptomyces azureus and Streptomyces laurentii. Thiostrepton is a natural product of the ribosomally synthesized and post-translationally...

Mechanism: Pharmacologically active on Proteasome subunit beta type-3
Curator reviewed
Formula / weight: C₇₂H₈₅N₁₉O₁₈S₅ · 1664.89 g/mol (avg)

Resolves to

Compound

UNIIHR4S203Y18ChEMBLCHEMBL410968

Clinical / RWD

RxNorm1365970

Structure

InChIKeyNSFFHOGKXHRQEW-DVRIZHICSA-NSMILES

[H]\C(C)=C1/N=C(O)C(N=C(O)C2=CSC(=N2)C23CCC(=NC2C2=CSC(=N2)C(N=C(O)C2=CSC(=N2)C(N=C(O)C2CSC1=N2)C(C)(O)C(C)O)C(C)OC(=O)C1=NC2=C(C=CC(NC(C(C)CC)C(O)=NC(C)C(O)=NC(=C)C(O)=NC(C)C(O)=N3)C2O)C(=C1)C(C)O)C1=NC(=CS1)C(O)=NC(=C)C(O)=NC(=C)C(O)=N)C(C)O

Targets

P49720PSMB3

What you can answer from here — as of July 07, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

56Drug interactionsStructured to mechanism, not free text

1Clinical trialPhase, status and sponsor resolved per trial

12+ReferencesStructured and connected to the statements they support

Which drugs share a target with Thiostrepton, and which of those have an active Phase 3 trial?

Answer this in Biopharma OS Sign in to your account

Create a free account or log in to explore the full data card.

Create Account