This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Iomeprol is an iodine-based X-ray contrast agent.

Generic Name
Iomeprol
DrugBank Accession Number
DB11705
Background

Iomeprol has been investigated for the diagnostic of Coronary Artery Disease.

Type
Small Molecule
Groups
Approved, Investigational
Structure
Weight
Average: 777.089
Monoisotopic: 776.8541
Chemical Formula
C17H22I3N3O8
Synonyms
  • Iomeprol
  • Iomeprolum
External IDs
  • E7337

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
IomeronInjection, solution816 mg/1mLIntravascularBIPSO GmbH2022-07-01Not applicableUS flag
IomeronInjection, solution510 mg/1mLIntravascularBIPSO GmbH2022-07-01Not applicableUS flag
IomeronInjection, solution714 mg/1mLIntravascularBracco Diagnostics Inc2022-07-01Not applicableUS flag
IomeronInjection, solution612 mg/1mLIntravascularBracco Diagnostics Inc2022-07-01Not applicableUS flag
IomeronInjection, solution714 mg/1mLIntravascularBIPSO GmbH2022-07-01Not applicableUS flag
IomeronInjection, solution714 mg/1mLIntravascularBIPSO GmbH2022-07-01Not applicableUS flag
IomeronInjection, solution816 mg/1mLIntravascularBracco Diagnostics Inc2022-07-01Not applicableUS flag
IomeronInjection, solution612 mg/1mLIntravascularBracco Diagnostics Inc2022-07-01Not applicableUS flag
IomeronInjection, solution612 mg/1mLIntravascularBIPSO GmbH2022-07-01Not applicableUS flag
IomeronInjection, solution816 mg/1mLIntravascularBracco Diagnostics Inc2022-07-01Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
IomeronIomeprol (816 mg/1mL)Injection, solutionIntravascularBIPSO GmbH2022-07-01Not applicableUS flag
IomeronIomeprol (510 mg/1mL)Injection, solutionIntravascularBIPSO GmbH2022-07-01Not applicableUS flag
IomeronIomeprol (714 mg/1mL)Injection, solutionIntravascularBracco Diagnostics Inc2022-07-01Not applicableUS flag
IomeronIomeprol (612 mg/1mL)Injection, solutionIntravascularBracco Diagnostics Inc2022-07-01Not applicableUS flag
IomeronIomeprol (714 mg/1mL)Injection, solutionIntravascularBIPSO GmbH2022-07-01Not applicableUS flag
IomeronIomeprol (714 mg/1mL)Injection, solutionIntravascularBIPSO GmbH2022-07-01Not applicableUS flag
IomeronIomeprol (816 mg/1mL)Injection, solutionIntravascularBracco Diagnostics Inc2022-07-01Not applicableUS flag
IomeronIomeprol (612 mg/1mL)Injection, solutionIntravascularBracco Diagnostics Inc2022-07-01Not applicableUS flag
IomeronIomeprol (612 mg/1mL)Injection, solutionIntravascularBIPSO GmbH2022-07-01Not applicableUS flag
IomeronIomeprol (816 mg/1mL)Injection, solutionIntravascularBracco Diagnostics Inc2022-07-01Not applicableUS flag

Categories

ATC Codes
V08AB10 — Iomeprol
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as acylaminobenzoic acid and derivatives. These are derivatives of amino benzoic acid derivatives where the amine group is N-acylated.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzoic acids and derivatives
Direct Parent
Acylaminobenzoic acid and derivatives
Alternative Parents
2-halobenzoic acids and derivatives / 4-halobenzoic acids and derivatives / Anilides / Benzamides / Benzoyl derivatives / Iodobenzenes / Aryl iodides / Vinylogous halides / Tertiary carboxylic acid amides / Secondary carboxylic acid amides
show 8 more
Substituents
2-halobenzoic acid or derivatives / 4-halobenzoic acid or derivatives / Acylaminobenzoic acid or derivatives / Alcohol / Anilide / Aromatic homomonocyclic compound / Aryl halide / Aryl iodide / Benzamide / Benzoyl
show 20 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
organoiodine compound, benzenedicarboxamide (CHEBI:31710)
Affected organisms
Not Available

Chemical Identifiers

UNII
17E17JBP8L
CAS number
78649-41-9
InChI Key
NJKDOADNQSYQEV-UHFFFAOYSA-N
InChI
InChI=1S/C17H22I3N3O8/c1-23(9(29)6-26)15-13(19)10(16(30)21-2-7(27)4-24)12(18)11(14(15)20)17(31)22-3-8(28)5-25/h7-8,24-28H,2-6H2,1H3,(H,21,30)(H,22,31)
IUPAC Name
N1,N3-bis(2,3-dihydroxypropyl)-5-(2-hydroxy-N-methylacetamido)-2,4,6-triiodobenzene-1,3-dicarboxamide
SMILES
CN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I

References

General References
  1. EMC Summary of Product Characteristics: Iomeron (iomeprol) solution for injection [Link]
KEGG Drug
D01719
PubChem Compound
3731
PubChem Substance
347828070
ChemSpider
3600
ChEBI
31710
ChEMBL
CHEMBL2107214
Wikipedia
Iomeprol

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedDiagnosticCoronary Artery Disease (CAD)1
4CompletedPreventionAngioplasty, Transluminal, Percutaneous Coronary / Coronary Arteriosclerosis / Renal Insufficiency,Chronic1
4CompletedSupportive CareContrast Agent With Lean Body Weight1
2, 3CompletedDiagnosticLiver Lesions1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, solutionIntravascular510 mg/1mL
Injection, solutionIntravascular612 mg/1mL
Injection, solutionIntravascular714 mg/1mL
Injection, solutionIntravascular816 mg/1mL
Injection, solutionParenteral
SolutionIntravenous816.5 mg
Injection, solutionParenteral306 mg/ml
Injection, solutionParenteral510 mg/ml
SolutionIntravenous300 mg/1ml
InjectionIntravascular300 mg/ml
Injection, solutionParenteral612 mg/ml
SolutionIntravenous350 mg/1ml
InjectionIntravascular350 mg/ml
Injection, solutionParenteral714 mg/ml
InjectionIntrathecal; Intravascular
SolutionIntravenous400 mg/1ml
InjectionIntravascular400 mg/ml
Injection, solutionParenteral817 mg/ml
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.595 mg/mLALOGPS
logP-2.5ALOGPS
logP-1.4ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)11.73ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count7ChemAxon
Polar Surface Area179.66 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity138.29 m3·mol-1ChemAxon
Polarizability55.44 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a4r-0000049400-095b92c1913741b28ec8
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a70-1010087900-3dc75b93e1362296e3f8
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0000910000-c35ce58fc36bb85b484d
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0035900000-49c23bf3a3d5d162933d
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-0292100000-375b1826ba908dc52d29
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-0690000000-50134c01bd57ba254445
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00kr-2940000000-a5e43bfc64d945f0572a
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0550-1000098800-25479ede47fc75d0ac1c
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0000910000-65a46359f46983d35c74
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0035900000-8e28e0e3a2feef5a7170
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-0292100000-5a987cc5321ffde2e24a
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-0690000000-2750b90b0b7508df5468
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-052r-2950000000-b08506fd442ea327e637
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a4r-0000049400-0c093cc1d48dbca685c6

Drug created at October 20, 2016 20:41 / Updated at May 07, 2021 21:07