Actin, cytoplasmic 1

BE0004966ProteinHumansACTB

Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). It is acted on by 4 drugs in DrugBank.

Gene name
ACTB
UniProtKB entry
P60709Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton
Residues / weight
375 residues · 41,736 Da
Also known as
3.6.4.- · Beta-actin

Resolves to

Protein
UniProtP60709UniProt nameACTB_HUMAN
Gene
HGNCHGNC:132NCBI Gene60GeneCardsACTB
Pharmacology
KEGGhsa:60
Structure
PDB3BYHPDB3D2UPDB3J82
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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68GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Actin, cytoplasmic 1, how selective are they, and which programs against it are still in active trials?

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