Rilotumumab

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Rilotumumab
DrugBank Accession Number
DB11972
Background

Rilotumumab has been investigated for the treatment of Cancer, Lung Cancer, Solid Tumors, Gastric Cancer, and Prostate Cancer, among others.

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • AMG 102
  • Rilotumumab

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Avoid life-threatening adverse drug events & improve clinical decision support.
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbciximabThe risk or severity of adverse effects can be increased when Abciximab is combined with Rilotumumab.
AdalimumabThe risk or severity of adverse effects can be increased when Adalimumab is combined with Rilotumumab.
AducanumabThe risk or severity of adverse effects can be increased when Rilotumumab is combined with Aducanumab.
AlemtuzumabThe risk or severity of adverse effects can be increased when Alemtuzumab is combined with Rilotumumab.
AlirocumabThe risk or severity of adverse effects can be increased when Alirocumab is combined with Rilotumumab.
AmivantamabThe risk or severity of adverse effects can be increased when Rilotumumab is combined with Amivantamab.
AnifrolumabThe risk or severity of adverse effects can be increased when Rilotumumab is combined with Anifrolumab.
AnsuvimabThe risk or severity of adverse effects can be increased when Rilotumumab is combined with Ansuvimab.
Anthrax immune globulin humanThe risk or severity of adverse effects can be increased when Anthrax immune globulin human is combined with Rilotumumab.
Antilymphocyte immunoglobulin (horse)The risk or severity of adverse effects can be increased when Antilymphocyte immunoglobulin (horse) is combined with Rilotumumab.
Interactions
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Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
51WEW898IJ
CAS number
872514-65-3

References

General References
Not Available
PubChem Substance
347911263
Wikipedia
Rilotumumab

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3TerminatedTreatmentMalignant Neoplasm of Stomach2
2CompletedTreatmentAdvanced Malignant Glioma1
2CompletedTreatmentAdvanced Renal Cell Carcinoma (aRCC)1
2CompletedTreatmentEsophageal Neoplasms Malignant / Malignant Neoplasm of Stomach1
2CompletedTreatmentGlioblastoma Multiforme (GBM) / Gliosarcoma1
2CompletedTreatmentRecurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma1
2WithdrawnTreatmentEpithelial Mesothelioma / Mesothelioma Malignant Advanced / Recurrent Malignant Mesothelioma / Sarcomatous Mesothelioma1
2, 3TerminatedTreatmentMET Positive / Recurrent Squamous Cell Lung Carcinoma / Stage IV Squamous Cell Lung Carcinoma AJCC v71
1CompletedTreatmentPart 1- Advanced Solid Tumors / Part 2- Advanced or Metastatic Gastric Cancer / Part 2- Advanced or Metastatic GEJ1
1, 2CompletedTreatmentAdenocarcinomas of the Gastroesophageal Junction / Esophageal Neoplasms Malignant / Malignant Neoplasm of Stomach1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created on October 20, 2016 21:07 / Updated on February 21, 2021 18:53