PF-04457845

DB12012InvestigationalSmall molecule

PF-04457845 is under investigation in Fear Conditioning. PF-04457845 has been investigated for the treatment of Tourette Syndrome and Cannabis Dependence.

Mechanism: Pharmacologically active on Fatty-acid amide hydrolase 1
Curator reviewed
Formula / weight: C₂₃H₂₀F₃N₅O₂ · 455.441 g/mol (avg)
Code names: PF-04457845

Resolves to

Compound

UNIIH4C81M8YYWCAS1020315-31-4ChEMBLCHEMBL1651534PubChem24771824

Structure

InChIKeyBATCTBJIJJEPHM-UHFFFAOYSA-NSMILESFC(F)(F)C1=CC=C(OC2=CC=CC(C=C3CCN(CC3)C(=O)NC3=CC=CN=N3)=C2)N=C1

Targets

O00519FAAH

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

8Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with PF-04457845, and which of those have an active Phase 3 trial?

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