Fatty-acid amide hydrolase 1

BE0002194ProteinHumansFAAH

Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these... It is acted on by 14 drugs in DrugBank.

Gene name
FAAH
UniProtKB entry
O00519Swiss-Prot
Cellular location
Endomembrane system
Residues / weight
579 residues · 63,065 Da
Also known as
3.5.1.99 · Anandamide amidohydrolase 1 · FAAH1 · Fatty acid ester hydrolase · Oleamide hydrolase 1

Resolves to

Protein
UniProtO00519UniProt nameFAAH1_HUMAN
Gene
HGNCHGNC:3553NCBI Gene2166GenBank2149156GeneCardsFAAH
Pharmacology
IUPHAR/GtoPdb1400KEGGhsa:2166
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Fatty-acid amide hydrolase 1, how selective are they, and which programs against it are still in active trials?

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