PF-05175157

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
PF-05175157
DrugBank Accession Number
DB12096
Background

PF-05175157 has been used in trials studying the basic science and treatment of Acne Vulgaris, Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes Mellitus Type 2, and Diabetes Mellitus, Type 2, among others.

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 405.502
Monoisotopic: 405.216475129
Chemical Formula
C23H27N5O2
Synonyms
Not Available

Pharmacology

Indication

Not Available

Reduce drug development failure rates
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as n-benzoylpiperidines. These are heterocyclic Compounds containing a piperidine ring conjugated to a benzyl group through one nitrogen ring atom.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Piperidines
Sub Class
N-acylpiperidines
Direct Parent
N-benzoylpiperidines
Alternative Parents
Benzimidazoles / Aryl alkyl ketones / Benzenoids / Tertiary carboxylic acid amides / Pyrazoles / Imidazoles / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds
show 2 more
Substituents
Aromatic heteropolycyclic compound / Aryl alkyl ketone / Aryl ketone / Azacycle / Azole / Benzenoid / Benzimidazole / Carboxamide group / Carboxylic acid derivative / Heteroaromatic compound
show 12 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
P826WR56FI
CAS number
1301214-47-0
InChI Key
BDXXSFOJPYSYOC-UHFFFAOYSA-N
InChI
InChI=1S/C23H27N5O2/c1-14(2)28-21-17(13-24-28)11-23(12-20(21)29)6-8-27(9-7-23)22(30)16-4-5-18-19(10-16)26-15(3)25-18/h4-5,10,13-14H,6-9,11-12H2,1-3H3,(H,25,26)
IUPAC Name
1'-(2-methyl-1H-1,3-benzodiazole-6-carbonyl)-1-(propan-2-yl)-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-7-one
SMILES
CC(C)N1N=CC2=C1C(=O)CC1(CCN(CC1)C(=O)C1=CC=C3N=C(C)NC3=C1)C2

References

General References
Not Available
PubChem Compound
52934180
PubChem Substance
347828400
ChemSpider
52083240
BindingDB
50034371
ChEMBL
CHEMBL3359265
ZINC
ZINC000117445039

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2TerminatedBasic ScienceType 2 Diabetes Mellitus3
2WithdrawnTreatmentAcne Vulgaris1
1CompletedBasic ScienceDiabetes Mellitus / Metabolism Disorder, Glucose / Type 2 Diabetes Mellitus1
1CompletedBasic ScienceHealthy Volunteers (HV)2
1CompletedBasic ScienceType 2 Diabetes Mellitus5

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0529 mg/mLALOGPS
logP2.24ALOGPS
logP1.72Chemaxon
logS-3.9ALOGPS
pKa (Strongest Acidic)11.36Chemaxon
pKa (Strongest Basic)6.01Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area83.88 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity126.12 m3·mol-1Chemaxon
Polarizability45.27 Å3Chemaxon
Number of Rings5Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-0003900000-eb25f2953fcbf3c4f584
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-0000900000-b8ddffc4b851bbeaac1e
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-0113900000-5bb2313557ddff382907
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0bt9-0019700000-2f3c7e457de621130054
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0f79-0029000000-4663487e8035654a55ba
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-053r-2946100000-6345069c28392722e3e1
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-193.60689
predicted
DeepCCS 1.0 (2019)
[M+H]+196.00246
predicted
DeepCCS 1.0 (2019)
[M+Na]+202.42003
predicted
DeepCCS 1.0 (2019)

Drug created at October 20, 2016 21:20 / Updated at June 12, 2020 16:53