Acetyl-CoA carboxylase 2

BE0000702ProteinHumansACACB

Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:19900410, PubMed:20457939, PubMed:20952656, PubMed:26976583). It is acted on by 11 drugs in DrugBank.

Gene name
ACACB
UniProtKB entry
O00763Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
2,458 residues · 276,539 Da
Also known as
6.4.1.2 · ACC-beta · ACC2 · ACCB

Resolves to

Protein
UniProtO00763UniProt nameACACB_HUMAN
Gene
HGNCHGNC:85NCBI Gene32GenBank2138330GeneCardsACACB
Pharmacology
IUPHAR/GtoPdb1264KEGGhsa:32
Structure
PDB2DN8PDB2HJWPDB2KCC
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Acetyl-CoA carboxylase 2, how selective are they, and which programs against it are still in active trials?

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