TRV-120027

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DB12199InvestigationalSmall molecule

TRV120027 has been used in trials studying the treatment of Heart Failure and Kidney Disease.

Mechanism: Pharmacologically active on Type-1 angiotensin II receptor
Curator reviewed
Formula / weight: C₄₃H₆₇N₁₃O₁₀ · 926.09 g/mol (avg)
Code names: TRV027 · TRV-120027

Resolves to

Compound

UNIIJ1J4P3PQZDCAS1234510-46-3PubChem3082475

Structure

InChIKeyXIEWFECSPPTVQN-KMIMAYJXSA-NSMILES

[H][C@](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC)C(C)C)([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(O)=O

Targets

P30556AGTR1

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

5Clinical trialsPhase, status and sponsor resolved per trial

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with TRV-120027, and which of those have an active Phase 3 trial?

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