Type-1 angiotensin II receptor

BE0000062ProteinHumansAGTR1

Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:15611106, PubMed:1567413, PubMed:25913193, PubMed:26420482, PubMed:30639100, PubMed:32079768, PubMed:8987975). It is acted on by 28 drugs in DrugBank.

Gene name
AGTR1
UniProtKB entry
P30556Swiss-Prot
Cellular location
Cell membrane
Residues / weight
359 residues · 41,061 Da
Also known as
AGTR1A · AGTR1B · Angiotensin II type-1 receptor · AT1 receptor · AT1AR

Resolves to

Protein
UniProtP30556UniProt nameAGTR1_HUMAN
Gene
HGNCHGNC:336NCBI Gene185GenBank179122GeneCardsAGTR1
Pharmacology
IUPHAR/GtoPdb34KEGGhsa:185
Structure
PDB4YAYPDB4ZUDPDB6DO1
Drugs

What you can answer from here — as of September 07, 2019

28DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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194+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Type-1 angiotensin II receptor, how selective are they, and which programs against it are still in active trials?

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