Verdinexor

DB12207InvestigationalSmall molecule

Kpt 335 is under investigation in clinical trial NCT02431364 (Trial of Safety and Tolerability of Oral Verdinexor (Verdinexor) in Healthy Adults).

Chemical structure of Verdinexor
Mechanism
Curator reviewed
Formula / weight
C18H12F6N6O · 442.325 g/mol (avg)
Code names
KPT-335

Resolves to

Compound
UNII85Q03215IWCAS1392136-43-4ChEMBLCHEMBL3545187PubChem71492799
Clinical / RWD
RxNorm2539289
Structure
InChIKeyOPAKEJZFFCECPN-XQRVVYSFSA-NSMILESFC(F)(F)C1=CC(=CC(=C1)C1=NN(\C=C/C(=O)NNC2=CC=CC=N2)C=N1)C(F)(F)F
Targets
O14980XPO1

What you can answer from here — as of August 30, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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1Clinical trialPhase, status and sponsor resolved per trial
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5+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Verdinexor, and which of those have an active Phase 3 trial?

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