Exportin-1

BE0009694ProteinHumansXPO1

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. It is acted on by 6 drugs in DrugBank.

Gene name
XPO1
UniProtKB entry
O14980Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,071 residues · 123,385 Da
Also known as
Chromosome region maintenance 1 protein homolog · CRM1 · Exp1

Resolves to

Protein
UniProtO14980UniProt nameXPO1_HUMAN
Gene
HGNCHGNC:12825NCBI Gene7514GeneCardsXPO1
Pharmacology
IUPHAR/GtoPdb3014KEGGhsa:7514
Structure
PDB1W9CPDB2L1LPDB3GB8
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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62+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Exportin-1, how selective are they, and which programs against it are still in active trials?

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