GS-5745

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
GS-5745
DrugBank Accession Number
DB12296
Background

GS-5745 has been used in trials studying the treatment of Tumors, Breast Cancer, Crohn's Disease, Colorectal Cancer, and Pancreatic Cancer, among others.

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Other protein based therapies
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
Not Available

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbciximabThe risk or severity of adverse effects can be increased when Abciximab is combined with GS-5745.
AdalimumabThe risk or severity of adverse effects can be increased when Adalimumab is combined with GS-5745.
AlemtuzumabThe risk or severity of adverse effects can be increased when Alemtuzumab is combined with GS-5745.
AlirocumabThe risk or severity of adverse effects can be increased when Alirocumab is combined with GS-5745.
AnsuvimabThe risk or severity of adverse effects can be increased when GS-5745 is combined with Ansuvimab.
Anthrax immune globulin humanThe risk or severity of adverse effects can be increased when Anthrax immune globulin human is combined with GS-5745.
Antilymphocyte immunoglobulin (horse)The risk or severity of adverse effects can be increased when Antilymphocyte immunoglobulin (horse) is combined with GS-5745.
Antithymocyte immunoglobulin (rabbit)The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with GS-5745.
Asfotase alfaThe risk or severity of adverse effects can be increased when Asfotase alfa is combined with GS-5745.
AtezolizumabThe risk or severity of adverse effects can be increased when Atezolizumab is combined with GS-5745.
Interactions
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Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
571045EIM4
CAS number
1518996-49-0

References

General References
Not Available
PubChem Substance
347911313

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentGastric Adenocarcinoma1
2CompletedTreatmentAdenocarcinomas of the Gastroesophageal Junction / Gastric Adenocarcinoma1
2TerminatedTreatmentCrohn's Disease (CD)1
2TerminatedTreatmentCystic Fibrosis (CF)1
2TerminatedTreatmentRheumatoid Arthritis1
2, 3TerminatedTreatmentUlcerative Colitis1
1CompletedTreatmentBreast Cancer / Colorectal Cancers / Esophagogastric Cancer / Malignant Neoplasm of Pancreas / Non-Small Cell Lung Carcinoma (NSCLC)1
1CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)1
1CompletedTreatmentRheumatoid Arthritis1
1CompletedTreatmentUlcerative Colitis2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created on October 20, 2016 21:51 / Updated on June 12, 2020 16:53