Matrix metalloproteinase-9

BE0000058ProteinHumansMMP9

Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (PubMed:12879005, PubMed:1480034, PubMed:2551898). It is acted on by 42 drugs in DrugBank.

Gene name
MMP9
UniProtKB entry
P14780Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix
Residues / weight
707 residues · 78,458 Da
Also known as
3.4.24.35 · 92 kDa gelatinase · 92 kDa type IV collagenase · CLG4B · Gelatinase B

Resolves to

Protein
UniProtP14780UniProt nameMMP9_HUMAN
Gene
HGNCHGNC:7176NCBI Gene4318GenBank177205GeneCardsMMP9
Pharmacology
IUPHAR/GtoPdb1633KEGGhsa:4318
Structure
PDB1GKCPDB1GKDPDB1ITV
Drugs

What you can answer from here — as of September 07, 2019

42DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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13GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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103+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Matrix metalloproteinase-9, how selective are they, and which programs against it are still in active trials?

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