Bitopertin

DB12426InvestigationalSmall molecule

Bitopertin has been used in trials studying the treatment of Schizophrenia and Obsessive-Compulsive Disorder.

Mechanism: Pharmacologically active on Sodium- and chloride-dependent glycine transporter 1
Curator reviewed
Formula / weight: C₂₁H₂₀F₇N₃O₄S · 543.46 g/mol (avg)
Code names: DISC-1459 · R-1678 · RG-1678 · RO-4917838 · RO-4917939

Resolves to

Compound

Structure

InChIKeyYUUGYIUSCYNSQR-LBPRGKRZSA-NSMILESC[C@H](OC1=CC=C(C=C1C(=O)N1CCN(CC1)C1=C(F)C=C(C=N1)C(F)(F)F)S(C)(=O)=O)C(F)(F)F

Targets

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

16Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Bitopertin, and which of those have an active Phase 3 trial?

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