Nepadutant

DB12538InvestigationalSmall molecule

Nepadutant has been used in trials studying the treatment of Colic, Infantile Colic, and Infantile Functional Gastrointestinal Disorders.

Mechanism: Pharmacologically active on Substance-K receptor
Curator reviewed
Formula / weight: C₄₅H₅₈N₁₀O₁₃ · 947.016 g/mol (avg)

Resolves to

Compound

UNIIXW59TYL1XHCAS183747-35-5ChEMBLCHEMBL1908318PubChem9876321

Structure

InChIKeyNGCNKEZHGRXHNL-WVWQGFTISA-NSMILES

CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](CC(=O)N[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3NC(C)=O)NC1=O)C(=O)N[C@@H](CC1=CNC3=CC=CC=C13)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N2

Targets

P21452TACR2

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

4Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Nepadutant, and which of those have an active Phase 3 trial?

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