Modufolin

DB12676InvestigationalSmall molecule

Modufolin is under investigation for the treatment of Osteosarcoma.

Chemical structure of Modufolin
Mechanism
Curator reviewed
Formula / weight
C20H23N7O6 · 457.4399 g/mol (avg)
Also known as
(6R,S)5,10-methylene-tetrahydrofolic acid · (6R)-5,10-METHYLENETETRAHYDROFOLATE · 6R-MTHF · D-N5,N10-METHYLENE-L-TETRAHYDROFOLIC ACID
Code names
ISO-901

Resolves to

Compound
UNIIZ8R4A37V9QCAS31690-11-6ChEMBLCHEMBL1234270ChEBI1989PubChem445117
Structure
InChIKeyQYNUQALWYRSVHF-OLZOCXBDSA-NSMILES[H][C@@]12CN(CN1C1=C(NC2)N=C(N)NC1=O)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
Targets
P04818TYMS

What you can answer from here — as of July 09, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
8Clinical trialsPhase, status and sponsor resolved per trial
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2+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Modufolin, and which of those have an active Phase 3 trial?

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