Thymidylate synthase

BE0000324ProteinHumansTYMS

Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the mitochondrial and nuclear de novo thymidylate biosynthesis... It is acted on by 31 drugs in DrugBank.

Gene name
TYMS
UniProtKB entry
P04818Swiss-Prot
Cellular location
Nucleus
Residues / weight
313 residues · 35,716 Da
Also known as
2.1.1.45 · TS · TSase

Resolves to

Protein
UniProtP04818UniProt nameTYSY_HUMAN
Gene
HGNCHGNC:12441NCBI Gene7298GenBank37479GeneCardsTYMS
Pharmacology
IUPHAR/GtoPdb2642KEGGhsa:7298
Structure
PDB1HVYPDB1HW3PDB1HW4
Drugs

What you can answer from here — as of September 07, 2019

31DrugsApproved to experimental, with action, bond type and pharmacological action
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54Clinical trialsTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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132+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Thymidylate synthase, how selective are they, and which programs against it are still in active trials?

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