AR-42

DB12707InvestigationalSmall molecule

AR-42 has been used in trials studying the treatment of Meningioma, Acoustic Neuroma, Testicular Lymphoma, Intraocular Lymphoma, and Vestibular Schwannoma, among others.

Mechanism: Pharmacologically active on Histone deacetylase 1 and Histone deacetylase
Curator reviewed
Formula / weight: C₁₈H₂₀N₂O₃ · 312.369 g/mol (avg)
Also known as: (S)-(+)-N-HYDROXY-4-(3-METHYL-2-PHENYL-BUTYRYLAMINO)-BENZAMIDE · (αS)-N-[4-[(Hydroxyamino)carbonyl]phenyl]-α-(1-methylethyl)benzeneacetamide · BENZENEACETAMIDE, N-(4-((HYDROXYAMINO)CARBONYL)PHENYL)-.ALPHA.-(1-METHYLETHYL)-, (.ALPHA.S)- · N-Hydroxy-4-(3-methyl-2-(S)phenyl-butyrylamino)benzamide · N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide
Code names: AR-42 · REC-2282 · (S)-HDAC 42

Resolves to

Compound

UNIIE0GG29V0AQCAS935881-37-1ChEMBLCHEMBL191482ChEBI188197PubChem6918848

Structure

InChIKeyLAMIXXKAWNLXOC-INIZCTEOSA-NSMILESCC(C)[C@H](C(=O)NC1=CC=C(C=C1)C(=O)NO)C1=CC=CC=C1

Targets

Q13547HDAC1

What you can answer from here — as of July 09, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

6Clinical trialsPhase, status and sponsor resolved per trial

11+ReferencesStructured and connected to the statements they support

Which drugs share a target with AR-42, and which of those have an active Phase 3 trial?

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