Histone deacetylase 1

BE0002365ProteinHumansHDAC1

Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:16762839, PubMed:17704056, PubMed:28497810). It is acted on by 32 drugs in DrugBank.

Gene name
HDAC1
UniProtKB entry
Q13547Swiss-Prot
Cellular location
Nucleus
Residues / weight
482 residues · 55,103 Da
Also known as
3.5.1.98 · HD1 · Protein deacetylase HDAC1 · Protein deacylase HDAC1 · RPD3L1

Resolves to

Protein
UniProtQ13547UniProt nameHDAC1_HUMAN
Gene
HGNCHGNC:4852NCBI Gene3065GenBank1277084GeneCardsHDAC1
Pharmacology
IUPHAR/GtoPdb2658KEGGhsa:3065
Structure
PDB4BKXPDB5ICNPDB6Z2J
Drugs

What you can answer from here — as of September 07, 2019

32DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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41GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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148+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Histone deacetylase 1, how selective are they, and which programs against it are still in active trials?

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