Buthionine sulfoximine

DB12870InvestigationalSmall molecule

Buthionine sulfoximine has been used in trials studying the treatment of Neuroblastoma and Melanoma (Skin).

Mechanism: Pharmacologically active on Glutamate--cysteine ligase catalytic subunit
Curator reviewed
Formula / weight: C₈H₁₈N₂O₃S · 222.3 g/mol (avg)
Also known as: Buthionine sulfoxamine · DL-buthionine-(S,R)-sulfoximine
Code names: NSC-381100

Resolves to

Compound

Structure

InChIKeyKJQFBVYMGADDTQ-UHFFFAOYSA-NSMILESCCCCS(=N)(=O)CCC(N)C(O)=O

Targets

What you can answer from here — as of July 07, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

39Drug interactionsStructured to mechanism, not free text

2Clinical trialsPhase, status and sponsor resolved per trial

8+ReferencesStructured and connected to the statements they support

Which drugs share a target with Buthionine sulfoximine, and which of those have an active Phase 3 trial?

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