Glutamate--cysteine ligase catalytic subunit

BE0000166ProteinHumansGCLC

Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis. It is acted on by 8 drugs in DrugBank.

Gene name
GCLC
UniProtKB entry
P48506Swiss-Prot
Residues / weight
637 residues · 72,765 Da
Also known as
6.3.2.2 · Gamma-ECS · Gamma-glutamylcysteine synthetase · GCS heavy chain · GLCL

Resolves to

Protein
UniProtP48506UniProt nameGSH1_HUMAN
Gene
HGNCHGNC:4311NCBI Gene2729GenBank183039GeneCardsGCLC
Pharmacology
KEGGhsa:2729
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamate--cysteine ligase catalytic subunit, how selective are they, and which programs against it are still in active trials?

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