Nolatrexed

DB12912ExperimentalSmall molecule

Nolatrexed is under investigation in clinical trial NCT00012324 (Nolatrexed Dihydrochloride Compared With Doxorubicin in Treating Patients With Recurrent or Unresectable Liver Cancer).

Mechanism: Pharmacologically active on Thymidylate synthase
Curator reviewed
Formula / weight: C₁₄H₁₂N₄OS · 284.34 g/mol (avg)

Resolves to

Compound

UNIIK75ZUN743QCAS147149-76-6ChEMBLCHEMBL320775PubChem108189

Structure

InChIKeyXHWRWCSCBDLOLM-UHFFFAOYSA-NSMILESCC1=CC=C2N=C(N)NC(=O)C2=C1SC1=CC=NC=C1

Targets

P04818TYMSP12461TMP1

What you can answer from here — as of June 15, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

48Drug interactionsStructured to mechanism, not free text

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Nolatrexed, and which of those have an active Phase 3 trial?

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