This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Remogliflozin etabonate
- DrugBank Accession Number
- DB12935
- Background
Remogliflozin etabonate has been used in trials studying the treatment and basic science of Type 2 Diabetes Mellitus and Diabetes Mellitus, Type 2.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Remogliflozin etabonate (DB12935)
- Weight
- Average: 522.595
Monoisotopic: 522.257730812 - Chemical Formula
- C26H38N2O9
- Synonyms
- Remogliflozin etabonate
- External IDs
- GSK-189075
- GSK-189075A
- GSK189075A
Pharmacology
- Indication
Not Available
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Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcarbose The risk or severity of hypoglycemia can be increased when Acarbose is combined with Remogliflozin etabonate. Acebutolol The therapeutic efficacy of Remogliflozin etabonate can be increased when used in combination with Acebutolol. Acetazolamide The therapeutic efficacy of Remogliflozin etabonate can be increased when used in combination with Acetazolamide. Acetohexamide The risk or severity of hypoglycemia can be increased when Acetohexamide is combined with Remogliflozin etabonate. Acetyl sulfisoxazole The therapeutic efficacy of Remogliflozin etabonate can be increased when used in combination with Acetyl sulfisoxazole. Acetylsalicylic acid The risk or severity of hypoglycemia can be increased when Acetylsalicylic acid is combined with Remogliflozin etabonate. Albiglutide The risk or severity of hypoglycemia can be increased when Albiglutide is combined with Remogliflozin etabonate. Alclometasone The risk or severity of hyperglycemia can be increased when Alclometasone is combined with Remogliflozin etabonate. Alogliptin The risk or severity of hypoglycemia can be increased when Alogliptin is combined with Remogliflozin etabonate. Amcinonide The risk or severity of hyperglycemia can be increased when Amcinonide is combined with Remogliflozin etabonate. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as o-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a O-glycosidic bond.
- Kingdom
- Organic compounds
- Super Class
- Organic oxygen compounds
- Class
- Organooxygen compounds
- Sub Class
- Carbohydrates and carbohydrate conjugates
- Direct Parent
- O-glycosyl compounds
- Alternative Parents
- Phenoxy compounds / Phenol ethers / Alkyl aryl ethers / Oxanes / Monosaccharides / Carbonic acid diesters / Pyrazoles / Heteroaromatic compounds / Secondary alcohols / Polyols show 8 more
- Substituents
- Acetal / Alcohol / Alkyl aryl ether / Aromatic heteromonocyclic compound / Azacycle / Azole / Benzenoid / Carbonic acid derivative / Carbonic acid diester / Carbonyl group show 18 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- TR0QT6QSUL
- CAS number
- 442201-24-3
- InChI Key
- UAOCLDQAQNNEAX-ABMICEGHSA-N
- InChI
- InChI=1S/C26H38N2O9/c1-7-33-26(32)34-13-20-21(29)22(30)23(31)25(36-20)37-24-19(16(6)28(27-24)14(2)3)12-17-8-10-18(11-9-17)35-15(4)5/h8-11,14-15,20-23,25,29-31H,7,12-13H2,1-6H3/t20-,21-,22+,23-,25+/m1/s1
- IUPAC Name
- ethyl [(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{[5-methyl-1-(propan-2-yl)-4-{[4-(propan-2-yloxy)phenyl]methyl}-1H-pyrazol-3-yl]oxy}oxan-2-yl]methyl carbonate
- SMILES
- CCOC(=O)OC[C@H]1O[C@@H](OC2=NN(C(C)C)C(C)=C2CC2=CC=C(OC(C)C)C=C2)[C@H](O)[C@@H](O)[C@@H]1O
References
- General References
- Not Available
- External Links
- PubChem Compound
- 9871420
- PubChem Substance
- 347829080
- ChemSpider
- 8047110
- ChEMBL
- CHEMBL2028665
- ZINC
- ZINC000003979756
- Wikipedia
- Remogliflozin_etabonate
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Diabetes Mellitus, Noninsulin Dependent / Type 2 Diabetes Mellitus 1 2 Completed Treatment Type 1 Diabetes Mellitus 1 2 Completed Treatment Type 2 Diabetes Mellitus 3 1 Completed Basic Science Type 2 Diabetes Mellitus 1 1 Completed Treatment Impaired Renal Function / Type 2 Diabetes Mellitus 1 1 Completed Treatment Obesity / Type 2 Diabetes Mellitus 1 1 Completed Treatment Type 2 Diabetes Mellitus 10
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.189 mg/mL ALOGPS logP 3.33 ALOGPS logP 3.52 ChemAxon logS -3.4 ALOGPS pKa (Strongest Acidic) 12.2 ChemAxon pKa (Strongest Basic) 1.49 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 9 ChemAxon Hydrogen Donor Count 3 ChemAxon Polar Surface Area 141.73 Å2 ChemAxon Rotatable Bond Count 12 ChemAxon Refractivity 144.61 m3·mol-1 ChemAxon Polarizability 55.03 Å3 ChemAxon Number of Rings 3 ChemAxon Bioavailability 0 ChemAxon Rule of Five No ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule Yes ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at October 21, 2016 01:25 / Updated at February 21, 2021 18:54