Sodium/glucose cotransporter 2

BE0004753ProteinHumansSLC5A2

Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1 (PubMed:20980548, PubMed:28592437, PubMed:34880493, PubMed:37217492, PubMed:38057552). It is acted on by 20 drugs in DrugBank.

Gene name
SLC5A2
UniProtKB entry
P31639Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
672 residues · 72,896 Da
Also known as
Low affinity sodium-glucose cotransporter · Na(+)/glucose cotransporter 2 · SGLT2 · Solute carrier family 5 member 2

Resolves to

Protein
UniProtP31639UniProt nameSC5A2_HUMAN
Gene
HGNCHGNC:11037NCBI Gene6524GeneCardsSLC5A2
Pharmacology
IUPHAR/GtoPdb916KEGGhsa:6524
Structure
PDB7VSIPDB7YNJPDB7YNK
Drugs

What you can answer from here — as of September 07, 2019

20DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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80+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium/glucose cotransporter 2, how selective are they, and which programs against it are still in active trials?

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