5-fluoro-2'-deoxycytidine

DB12957InvestigationalSmall molecule

5-fluoro-2'-deoxycytidine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, and Urinary Bladder Neoplasms, among others.

Mechanism: Pharmacologically active on DNA (cytosine-5)-methyltransferase 1
Curator reviewed
Formula / weight: C₉H₁₂FN₃O₄ · 245.2077 g/mol (avg)
Also known as: 5-fluorodeoxycytidine · FCdR · FDCYD
Code names: NSC-48006 · RO 5-1090

Resolves to

Compound

UNIIKUA4693H5WCAS10356-76-0ChEMBLCHEMBL1076257PubChem515328

Structure

InChIKeyIDYKCXHJJGMAEV-RRKCRQDMSA-NSMILESNC1=NC(=O)N(C=C1F)[C@H]1C[C@H](O)[C@@H](CO)O1

Targets

P26358DNMT1

What you can answer from here — as of July 07, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

3Clinical trialsPhase, status and sponsor resolved per trial

10+ReferencesStructured and connected to the statements they support

Which drugs share a target with 5-fluoro-2'-deoxycytidine, and which of those have an active Phase 3 trial?

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