DNA (cytosine-5)-methyltransferase 1

BE0000892ProteinHumansDNMT1

DNA methyltransferase that methylates CpG residues (PubMed:17200670, PubMed:18754681, PubMed:21745816, PubMed:26070743). It is acted on by 14 drugs in DrugBank.

Gene name
DNMT1
UniProtKB entry
P26358Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,616 residues · 183,164 Da
Also known as
2.1.1.37 · AIM · CXXC-type zinc finger protein 9 · CXXC9 · DNA methyltransferase HsaI

Resolves to

Protein
UniProtP26358UniProt nameDNMT1_HUMAN
Gene
HGNCHGNC:2976NCBI Gene1786GenBank1632819GeneCardsDNMT1
Pharmacology
IUPHAR/GtoPdb2605KEGGhsa:1786
Structure
PDB3EPZPDB3PTAPDB3SWR
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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16Clinical trialsTrials of drugs acting on it, by phase and status
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17GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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91+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA (cytosine-5)-methyltransferase 1, how selective are they, and which programs against it are still in active trials?

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