Gluconic Acid

Identification

Summary

Gluconic Acid is an electrolyte supplement used in total parenteral nutrition.

Brand Names
Isolyte S, Isolyte S pH 7.4, Isoplate, Normosol-R, Physiolyte, Physiosol, Plasma-lyte, Plasma-lyte 148, Plasma-lyte 148 In 5 % Dextrose, Plasmalyte A
Generic Name
Gluconic Acid
DrugBank Accession Number
DB13180
Background

Commonly found in salts with sodium and calcium. Gluconic acid or gluconate is used to maintain the cation-anion balance on electrolyte solutions.

Type
Small Molecule
Groups
Approved, Investigational
Structure
Weight
Average: 196.1553
Monoisotopic: 196.058302738
Chemical Formula
C6H12O7
Synonyms
  • D-Gluconic Acid
  • Dextronic acid
  • Maltonic acid
External IDs
  • E-574
  • INS no.574
  • INS-574
  • NSC-77381
  • Pentahydroxycaproic acid

Pharmacology

Indication

For use as part of electrolyte supplementation in total parenteral nutrition [FDA Label].

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to treatFluid lossCombination Product in combination with: Sodium acetate (DB09395), Sodium chloride (DB09153), Magnesium chloride (DB09407), Potassium chloride (DB00761)••••••••••••••••••••
Used in combination to treatShock, hemorrhagicCombination Product in combination with: Magnesium chloride (DB09407), Potassium chloride (DB00761), Sodium acetate (DB09395), Sodium chloride (DB09153)••••••••••••••••••••
Used in combination to treatMild metabolic acidosisCombination Product in combination with: Potassium chloride (DB00761), Sodium acetate (DB09395), Magnesium chloride (DB09407), D-glucose (DB01914), Potassium acetate (DB14498), Sodium chloride (DB09153)•••••••••••••••••••••• ••••••••
Used in combination to treatMild metabolic acidosisCombination Product in combination with: Magnesium chloride (DB09407), Sodium acetate (DB09395), Potassium chloride (DB00761), Sodium chloride (DB09153)••••••••••••••••••••
Used in combination to treatModerate metabolic acidosisCombination Product in combination with: Magnesium chloride (DB09407), Sodium chloride (DB09153), Sodium acetate (DB09395), Potassium chloride (DB00761)••••••••••••••••••••
Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Used as part of electrolyte salts to maintain cation-anion balance in solutions.

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe risk or severity of dehydration can be increased when Acetazolamide is combined with Gluconic Acid.
AlfentanilThe therapeutic efficacy of Gluconic Acid can be decreased when used in combination with Alfentanil.
AmilorideThe risk or severity of dehydration can be increased when Amiloride is combined with Gluconic Acid.
AmiodaroneThe therapeutic efficacy of Gluconic Acid can be decreased when used in combination with Amiodarone.
AmlodipineThe therapeutic efficacy of Gluconic Acid can be decreased when used in combination with Amlodipine.
Food Interactions
No interactions found.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Sodium gluconateR6Q3791S76527-07-1UPMFZISCCZSDND-JJKGCWMISA-M
Active Moieties
NameKindUNIICASInChI Key
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
BİOFLEKS İZOLEKS-S pH 7.4 ÇÖZELTİSİ 1000 ML (PVC TORBA) SETLİSodium gluconate (0.5 g/100ml) + Dipotassium phosphate (0.012 g/100ml) + Magnesium chloride hexahydrate (0.03 g/100ml) + Monopotassium phosphate (0.00082 g/100ml) + Potassium chloride (0.037 g/100ml) + Sodium acetate trihydrate (0.37 g/100ml) + Sodium chloride (0.53 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2003-01-01Not applicableTurkey flag
BİOFLEKS İZOLEKS-S pH 7.4 ÇÖZELTİSİ 500 ML (PVC TORBA) SETLİSodium gluconate (0.5 g/100ml) + Dipotassium phosphate (0.012 g/100ml) + Magnesium chloride hexahydrate (0.03 g/100ml) + Monopotassium phosphate (0.00082 g/100ml) + Potassium chloride (0.037 g/100ml) + Sodium acetate trihydrate (0.37 g/100ml) + Sodium chloride (0.53 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2003-01-01Not applicableTurkey flag
BİOFLEKS İZOLEKS-S pH 7.4 ÇÖZELTİSİ 500 ML (PVC TORBA) SETSİZSodium gluconate (0.5 g/100ml) + Dipotassium phosphate (0.012 g/100ml) + Magnesium chloride hexahydrate (0.03 g/100ml) + Monopotassium phosphate (0.00082 g/100ml) + Potassium chloride (0.037 g/100ml) + Sodium acetate trihydrate (0.37 g/100ml) + Sodium chloride (0.53 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2003-01-01Not applicableTurkey flag
ELETTROLITICA DI REINTEGRAZIONE CON POTASSIO, GLUCOSIO E SODIO GLUCONATO BIOINDUSTRIA L.I.M.Sodium gluconate (5.02 g/L) + Dextrose, unspecified form (50 g/L) + Magnesium chloride hexahydrate (0.31 g/L) + Potassium acetate (2.45 g/L) + Potassium chloride (0.37 g/L) + Sodium acetate trihydrate (3.67 g/L) + Sodium chloride (5.26 g/L)Injection, solutionIntravenousBioindustria Laboratorio Italiano Medicinali S.P.A.2014-07-082022-08-05Italy flag
ELETTROLITICA DI REINTEGRAZIONE CON POTASSIO, GLUCOSIO E SODIO GLUCONATO BIOINDUSTRIA L.I.M.Sodium gluconate (5.02 g/L) + Dextrose, unspecified form (50 g/L) + Magnesium chloride hexahydrate (0.31 g/L) + Potassium acetate (2.45 g/L) + Potassium chloride (0.37 g/L) + Sodium acetate trihydrate (3.67 g/L) + Sodium chloride (5.26 g/L)Injection, solutionIntravenousBioindustria Laboratorio Italiano Medicinali S.P.A.2014-07-082022-08-05Italy flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
GlorySmile toothpaste.Sodium gluconate (0.1 g/100g) + Sodium fluoride (0.1 g/100g)CreamTopicalLLRN PERSONAL CARE(SHENZHEN)CO., LTD2023-11-23Not applicableUS flag
Glorysmile Toothpaste.Sodium gluconate (0.1 g/100g) + Sodium fluoride (0.1 g/100g)CreamTopicalNanchang Dental Bright Technology Co.,Ltd.2023-11-19Not applicableUS flag
ISOLYTE SISE 1000 ML(SETLI)Sodium gluconate (0.5 %) + Magnesium chloride (0.03 %) + Monopotassium phosphate (0.00082 %) + Potassium chloride (0.037 %) + Sodium acetate trihydrate (0.37 %) + Sodium chloride (0.53 %) + Sodium phosphate, dibasic, heptahydrate (0.012 %)SolutionIntravenousECZACIBAŞI-BAXTER HASTANE ÜRÜNLERİ SAN.VE TİC. A.Ş.2019-08-062024-01-23Turkey flag
ISOLYTE SISE 1000 ML(SETSIZ)Sodium gluconate (0.5 %) + Magnesium chloride (0.03 %) + Monopotassium phosphate (0.00082 %) + Potassium chloride (0.037 %) + Sodium acetate trihydrate (0.37 %) + Sodium chloride (0.53 %) + Sodium phosphate, dibasic, heptahydrate (0.012 %)SolutionIntravenousECZACIBAŞI-BAXTER HASTANE ÜRÜNLERİ SAN.VE TİC. A.Ş.2019-08-062024-01-23Turkey flag
ISOLYTE SISE 500 ML(SETSIZ)Sodium gluconate (0.5 %) + Magnesium chloride (0.03 %) + Monopotassium phosphate (0.00082 %) + Potassium chloride (0.037 %) + Sodium acetate trihydrate (0.37 %) + Sodium chloride (0.53 %) + Sodium phosphate, dibasic, heptahydrate (0.012 %)SolutionIntravenousECZACIBAŞI-BAXTER HASTANE ÜRÜNLERİ SAN.VE TİC. A.Ş.2019-08-062024-01-23Turkey flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as sugar acids and derivatives. These are compounds containing a saccharide unit which bears a carboxylic acid group.
Kingdom
Organic compounds
Super Class
Organic oxygen compounds
Class
Organooxygen compounds
Sub Class
Carbohydrates and carbohydrate conjugates
Direct Parent
Sugar acids and derivatives
Alternative Parents
Medium-chain hydroxy acids and derivatives / Medium-chain fatty acids / Hydroxy fatty acids / Beta hydroxy acids and derivatives / Monosaccharides / Alpha hydroxy acids and derivatives / Secondary alcohols / Polyols / Monocarboxylic acids and derivatives / Carboxylic acids
show 4 more
Substituents
Alcohol / Aliphatic acyclic compound / Alpha-hydroxy acid / Beta-hydroxy acid / Carbonyl group / Carboxylic acid / Carboxylic acid derivative / Fatty acid / Fatty acyl / Gluconic_acid
show 11 more
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
gluconic acid (CHEBI:33198) / Uronic acids (C00257)
Affected organisms
Not Available

Chemical Identifiers

UNII
R4R8J0Q44B
CAS number
526-95-4
InChI Key
RGHNJXZEOKUKBD-SQOUGZDYSA-N
InChI
InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3-,4+,5-/m1/s1
IUPAC Name
(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
SMILES
OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O

References

General References
Not Available
Human Metabolome Database
HMDB0000625
KEGG Compound
C00257
PubChem Compound
10690
PubChem Substance
347829282
ChemSpider
10240
ChEBI
33198
ChEMBL
CHEMBL464345
ZINC
ZINC000001531008
PharmGKB
PA449770
PDBe Ligand
GCO
Wikipedia
Gluconic_acid
PDB Entries
1bgg / 1xlf / 3o03 / 3oy8 / 3qke / 3t6c / 3twb / 4k2s / 4zlg / 6e9n
show 2 more

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentHypovolaemia1
4RecruitingTreatmentHypotension During Surgery1
4TerminatedTreatmentDehydration / Gastroenteritis1
4Unknown StatusBasic ScienceNephrotoxicity1
3CompletedPreventionAcute Kidney Injury (AKI) / Critically Ill Patients1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CreamTopical
SolutionIntravenous
LiquidIntravenous
Injection, solution, concentrateIntravenous
IrrigantIrrigation
Injection, solutionIntravenous
InjectionIntravenous30 mg/100ml
SolutionParenteral
Powder, for solutionIrrigation; Topical
Prices
Not Available
Patents
Not Available

Properties

State
Liquid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility159.0 mg/mLALOGPS
logP-2.6ALOGPS
logP-3.4Chemaxon
logS-0.09ALOGPS
pKa (Strongest Acidic)3.39Chemaxon
pKa (Strongest Basic)-3Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count7Chemaxon
Hydrogen Donor Count6Chemaxon
Polar Surface Area138.45 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity38.27 m3·mol-1Chemaxon
Polarizability17.15 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)GC-MSsplash10-0002-0932000000-202af87cea2d1f7184ab
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)GC-MSsplash10-005a-0920000000-2308d9356bc5bb01420e
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)GC-MSsplash10-014j-0950000000-61ab7adf15e353df4ba2
GC-MS Spectrum - GC-MS (6 TMS)GC-MSsplash10-0le9-1964000000-5eb7d6777170e1ad5fa0
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-06tu-9500000000-ebe398c88f74bb51e702
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-0002-0932000000-202af87cea2d1f7184ab
GC-MS Spectrum - GC-MSGC-MSsplash10-0le9-1964000000-5eb7d6777170e1ad5fa0
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-0002-0931000000-b07fcc4ac1e6701d32c8
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-0fr2-0930000000-181f7b697b591cf8080b
MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)LC-MS/MSsplash10-06vj-1900000000-78e4a5d92be678c068e4
MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)LC-MS/MSsplash10-03ds-5900000000-f5d8284baa473ce9d77f
MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)LC-MS/MSsplash10-014i-9500000000-7c5b20eef98d0e3d6cbb
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, NegativeLC-MS/MSsplash10-0002-0900000000-b2632ca9154cc5e44438
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, NegativeLC-MS/MSsplash10-002b-5900000000-4a3066f9dfd6653682fb
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, NegativeLC-MS/MSsplash10-004i-9000000000-50f63dfd017a8380a47c
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, NegativeLC-MS/MSsplash10-056r-9000000000-91ccf7c8949c1c9d852a
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, NegativeLC-MS/MSsplash10-0a6r-9000000000-6e40f1cebd8b460016b3
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0002-0900000000-b2632ca9154cc5e44438
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-002b-5900000000-cf9b480ac397acfebc71
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-004i-9000000000-eca61f6a9c0f1d06e84d
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-056r-9000000000-91ccf7c8949c1c9d852a
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0a6r-9000000000-6e40f1cebd8b460016b3
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-03di-2900000000-6fda43c9fef438df3676
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-05g0-9300000000-ecedaa751adf4ecf0378
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-03kc-9000000000-a137e6b37990b449d33e
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-9000000000-8599bc330d1a2d774c4e
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-03di-9000000000-daba51d23da2e1f96d1e
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-9000000000-af7a585f71c6ec72847b
1H NMR Spectrum1D NMRNot Applicable
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
[1H,1H] 2D NMR Spectrum2D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-143.9014502
predicted
DarkChem Lite v0.1.0
[M-H]-127.1746795
predicted
DarkChem Standard v0.1.0
[M-H]-143.0163502
predicted
DarkChem Lite v0.1.0
[M-H]-142.7071502
predicted
DarkChem Lite v0.1.0
[M-H]-146.64145
predicted
DeepCCS 1.0 (2019)
[M+H]+144.4297502
predicted
DarkChem Lite v0.1.0
[M+H]+145.3866502
predicted
DarkChem Lite v0.1.0
[M+H]+144.0472502
predicted
DarkChem Lite v0.1.0
[M+H]+144.2574502
predicted
DarkChem Lite v0.1.0
[M+H]+149.03702
predicted
DeepCCS 1.0 (2019)
[M+Na]+143.6510502
predicted
DarkChem Lite v0.1.0
[M+Na]+145.9973614
predicted
DarkChem Standard v0.1.0
[M+Na]+143.4805502
predicted
DarkChem Lite v0.1.0
[M+Na]+143.2285502
predicted
DarkChem Lite v0.1.0
[M+Na]+154.94954
predicted
DeepCCS 1.0 (2019)

Drug created at June 09, 2017 02:30 / Updated at June 12, 2020 16:53