Aldo-keto reductase family 1 member B1

BE0000747ProteinHumansAKR1B1

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. It is acted on by 62 drugs in DrugBank.

Gene name
AKR1B1
UniProtKB entry
P15121Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
316 residues · 35,853 Da
Also known as
1.1.1.21 · 1.1.1.300 · 1.1.1.372 · 1.1.1.54 · Aldehyde reductase

Resolves to

Protein
UniProtP15121UniProt nameALDR_HUMAN
Gene
HGNCHGNC:381NCBI Gene231GenBank178487GeneCardsAKR1B1
Pharmacology
IUPHAR/GtoPdb2768KEGGhsa:231
Structure
PDB1ABNPDB1ADSPDB1AZ1
Drugs

What you can answer from here — as of September 03, 2024

62DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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195+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aldo-keto reductase family 1 member B1, how selective are they, and which programs against it are still in active trials?

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