Phthalylsulfathiazole

DB13248ApprovedSmall molecule

Phthalylsulfathiazole is a sulfonamide antibacterial indicated in the treatment of gastrointestinal infections. Phthalylsulfathiazole is a broad spectrum antibiotic which is part of the drug class, sulfonamides.

Mechanism: Phthalylsulfathiazole is a prodrug: Once administered, phthalylsulfathiazole releases its active metabolite, sulfathiazole, which targets the bacterial folate synthesis pathway by inhibiting the dihydropteroate synthase enzyme.
Curator reviewed · 1 reference
Formula / weight: C₁₇H₁₃N₃O₅S₂ · 403.43 g/mol (avg)

Resolves to

Compound

UNII6875L5852VCAS85-73-4ChEMBLCHEMBL1524273ChEBI9336KEGGC07659

Clinical / RWD

RxNorm33632ATCA07AB02ATCG01AE10

Structure

InChIKeyPBMSWVPMRUJMPE-UHFFFAOYSA-NSMILESOC(=O)C1=CC=CC=C1C(=O)NC1=CC=C(C=C1)S(=O)(=O)NC1=NC=CS1

Targets

Q81VW8folP

What you can answer from here — as of September 16, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

115Drug interactionsStructured to mechanism, not free text

7Structured indicationsCondition, population, route and combination as fields, not prose

7Marketed productsAcross 2 countries and 4 labellers

2ATC codesIncluding every combination product, plus 13 drug categories

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Phthalylsulfathiazole, and which of those have an active Phase 3 trial?

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