Dihydropteroate synthase

BE0003133ProteinBacillus anthracisfolP

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. It is acted on by 5 drugs in DrugBank.

Gene name
folP
UniProtKB entry
Q81VW8TrEMBL
Residues / weight
280 residues · 30,975 Da
Also known as
2.5.1.15 · DHPS · Dihydropteroate pyrophosphorylase

Resolves to

Protein
UniProtQ81VW8UniProt nameQ81VW8_BACAN
Pharmacology
KEGGbar:GBAA_0071
Structure
PDB1TWSPDB1TWWPDB1TWZ
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dihydropteroate synthase, how selective are they, and which programs against it are still in active trials?

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