Clothiapine

DB13256ApprovedSmall molecule

Clothiapine is an atypical antipsychotic indicated in the treatment of acute psychosis, exacerbations of chronic psychosis, chronic psychosis, paranoid psychosis, and anxiety. Clothiapine has been approved in European countries and is an atypical antipsychotic, shown to be useful in some treatment-resistant patients.

Chemical structure of Clothiapine
Mechanism
Curator reviewed
Formula / weight
C18H18ClN3S · 343.87 g/mol (avg)
Also known as
Clotiapine
Code names
HF-2159

Resolves to

Compound
UNIIZ05HCY0X1TCAS2058-52-8ChEMBLCHEMBL304902ChEBI31424
Clinical / RWD
RxNorm2620ATCN05AH06
Structure
InChIKeyKAAZGXDPUNNEFN-UHFFFAOYSA-NSMILESCN1CCN(CC1)C1=NC2=CC=CC=C2SC2=C1C=C(Cl)C=C2
Targets
P21917DRD4

What you can answer from here — as of June 15, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
718Drug interactionsStructured to mechanism, not free text
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1Clinical trialPhase, status and sponsor resolved per trial
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4Structured indicationsCondition, population, route and combination as fields, not prose
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10ContraindicationsEach with its own population and attribute set
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3Marketed productsAcross 1 country and 1 labeller
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1ATC codeIncluding every combination product, plus 13 drug categories
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13+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Clothiapine, and which of those have an active Phase 3 trial?

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