Dopamine receptor D4

BE0000389ProteinHumansDRD4

G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:16423344, PubMed:1840645, PubMed:27659709, PubMed:29051383, PubMed:37221270, PubMed:7512953, PubMed:7643093, PubMed:8078498, PubMed:8413587). It is acted on by 46 drugs in DrugBank.

Gene name
DRD4
UniProtKB entry
P21917Swiss-Prot
Cellular location
Cell membrane
Residues / weight
419 residues · 43,901 Da
Also known as
D(2C) dopamine receptor · Dopamine D4 receptor

Resolves to

Protein
UniProtP21917UniProt nameDRD4_HUMAN
Gene
HGNCHGNC:3025NCBI Gene1815GenBank291946GeneCardsDRD4
Pharmacology
IUPHAR/GtoPdb217KEGGhsa:1815
Structure
PDB5WIUPDB5WIVPDB8IRU
Drugs

What you can answer from here — as of September 08, 2026

46DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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17GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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150+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dopamine receptor D4, how selective are they, and which programs against it are still in active trials?

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