This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Summary
Acriflavine is a topical antiseptic indicated in the treatment of infected wounds and for skin disinfection.
- Generic Name
- Acriflavine
- DrugBank Accession Number
- DB13373
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Acriflavine (DB13373)
- Weight
- Average: 468.99
Monoisotopic: 468.1829225 - Chemical Formula
- C27H25ClN6
- Synonyms
- Acriflavinium chloride
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Treatment of Skin infections ••• ••• •••••• •••••• Treatment of Skin infections ••• ••• •••••• •••••• Prophylaxis of Skin infections ••• ••• •••••• •••••• Prophylaxis of Skin infections ••• ••• •••••• •••••• Treatment of Skin infections ••• ••• •••••• •••••• - Associated Therapies
- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism AGag-Pol polyprotein modulator- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Acriflavine hydrochloride 1S73VW819C 69235-50-3 MKLTXAHQKDVBLY-UHFFFAOYSA-N - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image ACRIFLAVINE SOLUTION 0.2% Solution 0.2 % Topical CHULIA PHARMA SDN BHD 2017-10-03 2019-09-11 Malaysia 
Acrisept Lotion 0.2% w/v Lotion 0.2 %w/v Cutaneous WINWA MEDICAL SDN. BHD. 2020-09-08 Not applicable Malaysia APP YELLOW SOLUTION 0.5% Solution 0.5 % Topical ROYCE PHARMA MANUFACTURING SDN. BHD. 2020-09-08 Not applicable Malaysia DERMOPLEX BURN AID CREAM Cream 0.1 % Occlusive dressing technique DUOPHARMA MANUFACTURING (BANGI) SDN. BHD. 2020-09-08 Not applicable Malaysia DYNA YELLOW LOTION Lotion 0.2 % w/v Topical DYNAPHARM (M) SDN. BHD. 2020-09-08 Not applicable Malaysia - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image YELLOW LOTION 0.4% Acriflavine (0.4 %) + Sodium benzoate (0.15 %) Lotion Topical WINWA MEDICAL SDN. BHD. 2020-09-08 Not applicable Malaysia อัยริน Acriflavine (2 ML/100ML) + Boric acid (2000 mg/100ML) + Zinc sulfate (50 MG/100ML) Liquid Ophthalmic บริษัท โรต้าลาบอเร็ทตอรี่ส์ จำกัด จำกัด 1986-06-27 Not applicable Thailand 
Categories
- ATC Codes
- R02AA13 — Acriflavinium chloride
- Drug Categories
- Acridines
- Aminoacridines
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Coloring Agents
- Compounds used in a research, industrial, or household setting
- Fluorescent Dyes
- Heterocyclic Compounds, Fused-Ring
- Indicators and Reagents
- Intercalating Agents
- Laboratory Chemicals
- Luminescent Agents
- Throat Preparations
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 1T3A50395T
- CAS number
- 65589-70-0
- InChI Key
- PEJLNXHANOHNSU-UHFFFAOYSA-N
- InChI
- InChI=1S/C14H13N3.C13H11N3.ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;1H
- IUPAC Name
- 3,6-diamino-10-methylacridin-10-ium acridine-3,6-diamine chloride
- SMILES
- [Cl-].NC1=CC2=NC3=C(C=CC(N)=C3)C=C2C=C1.C[N+]1=C2C=C(N)C=CC2=CC2=C1C=C(N)C=C2
References
- General References
- External Links
- KEGG Compound
- C11273
- ChemSpider
- 391386
- 249
- ChEMBL
- CHEMBL2360628
- Wikipedia
- Acriflavine
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data4 Completed Treatment Urinary Tract Infection 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Topical 0.2 % Lotion Cutaneous 0.2 %w/v Solution Topical 0.5 % Cream Occlusive dressing technique 0.1 % Lotion Topical 0.2 % w/v Cream Topical 0.1 %W/W Lotion Occlusive dressing technique; Topical 0.1 % W/V Lotion Cutaneous 0.1 % Lotion Topical Lotion Topical 0.4 % Cream Occlusive dressing technique; Topical Solution Topical Lotion Topical 0.1 %w/v Lotion Cutaneous 0.4 % Cream Topical Lotion Topical Solution Topical 0.15 g/100mL Solution Topical 0.1 g/100mL Solution Topical 0.2 g/100mL Liquid Ophthalmic - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP -2.8 Chemaxon pKa (Strongest Basic) 2.35 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 55.92 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 72.11 m3·mol-1 Chemaxon Polarizability 25.45 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Targets
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- Kind
- Protein
- Organism
- Not Available
- Pharmacological action
- Yes
- Actions
- Modulator
- General Function
- Gag-Pol polyprotein Mediates, with Gag polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi). Gag-Pol polyprotein may regulate its own translation, by the binding genomic RNA in the 5'-UTR. At low concentration, the polyprotein would promote translation, whereas at high concentration, the polyprotein would encapsidate genomic RNA and then shut off translation.
- Specific Function
- aspartic-type endopeptidase activity
- Gene Name
- gag-pol
- Uniprot ID
- P03366
- Uniprot Name
- Gag-Pol polyprotein
- Molecular Weight
- 163287.51 Da
References
- Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]
Drug created at June 23, 2017 20:40 / Updated at August 26, 2024 19:22