Acriflavine
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Acriflavine is a topical antiseptic indicated in the treatment of infected wounds and for skin disinfection.
- Generic Name
- Acriflavine
- DrugBank Accession Number
- DB13373
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 468.99
Monoisotopic: 468.1829225 - Chemical Formula
- C27H25ClN6
- Synonyms
- Acriflavinium chloride
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Treatment of Skin infections ••• ••• •••••• •••••• Treatment of Skin infections ••• ••• •••••• •••••• Prophylaxis of Skin infections ••• ••• •••••• •••••• Prophylaxis of Skin infections ••• ••• •••••• •••••• Treatment of Skin infections ••• ••• •••••• •••••• - Associated Therapies
- Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Acriflavine hydrochloride 1S73VW819C 69235-50-3 MKLTXAHQKDVBLY-UHFFFAOYSA-N - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image ACRIFLAVINE SOLUTION 0.2% Solution 0.2 % Topical CHULIA PHARMA SDN BHD 2017-10-03 2019-09-11 Malaysia Acrisept Lotion 0.2%w/v Lotion Cutaneous WINWA MEDICAL SDN. BHD. 2020-09-08 Not applicable Malaysia APP YELLOW SOLUTION 0.5% Solution 0.5 % Topical ROYCE PHARMA MANUFACTURING SDN. BHD. 2020-09-08 Not applicable Malaysia DERMOPLEX BURN AID CREAM Cream Occlusive dressing technique DUOPHARMA MANUFACTURING (BANGI) SDN BHD 2020-09-08 Not applicable Malaysia DYNA YELLOW LOTION Lotion Topical DYNAPHARM (M) SDN BHD 2020-09-08 Not applicable Malaysia - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image YELLOW LOTION 0.4% Acriflavine (0.4 %) + Sodium benzoate (0.15 %) Lotion Topical WINWA MEDICAL SDN. BHD. 2020-09-08 Not applicable Malaysia อัยริน Acriflavine (2 ML/100ML) + Boric acid (2000 mg/100ML) + Zinc sulfate (50 MG/100ML) Liquid Ophthalmic บริษัท โรต้าลาบอเร็ทตอรี่ส์ จำกัด จำกัด 1986-06-27 Not applicable Thailand
Categories
- ATC Codes
- R02AA13 — Acriflavinium chloride
- Drug Categories
- Acridines
- Aminoacridines
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Coloring Agents
- Compounds used in a research, industrial, or household setting
- Fluorescent Dyes
- Heterocyclic Compounds, Fused-Ring
- Indicators and Reagents
- Intercalating Agents
- Laboratory Chemicals
- Luminescent Agents
- Throat Preparations
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 1T3A50395T
- CAS number
- 65589-70-0
- InChI Key
- PEJLNXHANOHNSU-UHFFFAOYSA-N
- InChI
- InChI=1S/C14H13N3.C13H11N3.ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;1H
- IUPAC Name
- 3,6-diamino-10-methylacridin-10-ium acridine-3,6-diamine chloride
- SMILES
- [Cl-].NC1=CC2=NC3=C(C=CC(N)=C3)C=C2C=C1.C[N+]1=C2C=C(N)C=CC2=CC2=C1C=C(N)C=C2
References
- General References
- External Links
- KEGG Compound
- C11273
- ChemSpider
- 391386
- 249
- ChEMBL
- CHEMBL2360628
- Wikipedia
- Acriflavine
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Urinary Tract Infection 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Topical 0.2 % Solution Topical 0.5 % Cream Occlusive dressing technique Lotion Topical Lotion Occlusive dressing technique; Topical Lotion Cutaneous 0.1 % Cream Occlusive dressing technique; Topical Solution Topical Lotion Cutaneous Lotion Cutaneous 0.4 % Cream Topical Lotion Topical Solution Topical 0.15 g/100mL Solution Topical 0.1 g/100mL Solution Topical 0.2 g/100mL Liquid Ophthalmic - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP -2.8 Chemaxon pKa (Strongest Basic) 2.35 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 55.92 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 72.11 m3·mol-1 Chemaxon Polarizability 25.45 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at June 23, 2017 20:40 / Updated at June 02, 2021 20:04