This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Acriflavine is a topical antiseptic indicated in the treatment of infected wounds and for skin disinfection.

Generic Name
Acriflavine
DrugBank Accession Number
DB13373
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 468.99
Monoisotopic: 468.1829225
Chemical Formula
C27H25ClN6
Synonyms
  • Acriflavinium chloride

Pharmacology

Indication

Not Available

Pharmacology
Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
Improve clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events & improve clinical decision support.
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.
Learn more
Improve decision support & research outcomes with our structured adverse effects data.
Learn more
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Products2
Drug product information from 10+ global regions
Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
Access now
Access drug product information from over 10 global regions.
Access now
Product Ingredients
IngredientUNIICASInChI Key
Acriflavine hydrochloride1S73VW819C69235-50-3MKLTXAHQKDVBLY-UHFFFAOYSA-N
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
ACRIFLAVINE SOLUTION 0.2%Solution0.2 %TopicalCHULIA PHARMA SDN BHD2017-10-032019-09-11Malaysia flag
Acrisept Lotion 0.2%w/vLotionCutaneousWINWA MEDICAL SDN. BHD.2020-09-08Not applicableMalaysia flag
APP YELLOW SOLUTION 0.5%Solution0.5 %TopicalROYCE PHARMA MANUFACTURING SDN. BHD.2020-09-08Not applicableMalaysia flag
DERMOPLEX BURN AID CREAMCreamOcclusive dressing techniqueDUOPHARMA MANUFACTURING (BANGI) SDN BHD2020-09-08Not applicableMalaysia flag
DYNA YELLOW LOTIONLotionTopicalDYNAPHARM (M) SDN BHD2020-09-08Not applicableMalaysia flag
FLAVISEPT CREAM 0.1%W/WCreamTopicalZONTRON PHARMACEUTICALS SDN. BHD.2020-09-08Not applicableMalaysia flag
FLAVISEPT LOTION 0.1% W/VLotionOcclusive dressing technique; TopicalTERAPUTICS SDN BHD2020-09-08Not applicableMalaysia flag
NW ACRIFLAVINE LOTION 0.1%Lotion0.1 %CutaneousNATURAL WELLNESS INDUSTRIES SDN. BHD. (MILIK PENUH NUTRIVENTION SDN. BHD)2020-09-08Not applicableMalaysia flag
POLYLAB ACRIFLAVINE LOTION 0.4%LotionTopicalPOLYLAB BIOTECH SDN. BHD.2020-09-08Not applicableMalaysia flag
POLYLAB ACRIFLAVINE LOTION 0.4%LotionTopicalPOLYLAB BIOTECH SDN. BHD.2020-09-08Not applicableMalaysia flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
YELLOW LOTION 0.4%Acriflavine (0.4 %) + Sodium benzoate (0.15 %)LotionTopicalWINWA MEDICAL SDN. BHD.2020-09-08Not applicableMalaysia flag
อัยรินAcriflavine (2 ML/100ML) + Boric acid (2000 mg/100ML) + Zinc sulfate (50 MG/100ML)LiquidOphthalmicบริษัท โรต้าลาบอเร็ทตอรี่ส์ จำกัด จำกัด1986-06-27Not applicableThailand flag

Categories

ATC Codes
R02AA13 — Acriflavinium chloride
Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
1T3A50395T
CAS number
65589-70-0
InChI Key
PEJLNXHANOHNSU-UHFFFAOYSA-N
InChI
InChI=1S/C14H13N3.C13H11N3.ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;1H
IUPAC Name
3,6-diamino-10-methylacridin-10-ium acridine-3,6-diamine chloride
SMILES
[Cl-].NC1=CC2=NC3=C(C=CC(N)=C3)C=C2C=C1.C[N+]1=C2C=C(N)C=CC2=CC2=C1C=C(N)C=C2

References

General References
  1. FDA Thailand Product Information: Flavinol (euflavine/thymol) for topical use [Link]
  2. NPRA Product Information: PRIME'S acriflavine topical cream [Link]
KEGG Compound
C11273
ChemSpider
391386
RxNav
249
ChEMBL
CHEMBL2360628
Wikipedia
Acriflavine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentUrinary Tract Infection1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionTopical0.2 %
SolutionTopical0.5 %
CreamOcclusive dressing technique
LotionTopical
LotionOcclusive dressing technique; Topical
LotionCutaneous0.1 %
CreamOcclusive dressing technique; Topical
SolutionTopical
LotionCutaneous
LotionCutaneous0.4 %
CreamTopical
LotionTopical
SolutionTopical0.15 g/100mL
SolutionTopical0.1 g/100mL
SolutionTopical0.2 g/100mL
LiquidOphthalmic
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-2.8ChemAxon
pKa (Strongest Basic)2.35ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area55.92 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity72.11 m3·mol-1ChemAxon
Polarizability25.45 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at June 23, 2017 20:40 / Updated at June 02, 2021 20:04