Fenticonazole

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Fenticonazole is an imidazole antifungal used to treat a variety of topical fungal infections.

Generic Name
Fenticonazole
DrugBank Accession Number
DB13434
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 455.4
Monoisotopic: 454.0673398
Chemical Formula
C24H20Cl2N2OS
Synonyms
  • Fenticonazole

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Treatment ofBalanitis••• •••••••••
Treatment ofBalanoposthitis••• •••••••••
Treatment ofCandidiasis of skin nos••• •••••••••
Treatment ofDermatomycoses••• •••••••••
Treatment ofErythrasma••• •••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Fenticonazole nitrate8V4JGC8YRF73151-29-8FJNRUWDGCVDXLU-UHFFFAOYSA-N

Categories

ATC Codes
D01AC12 — FenticonazoleG01AF12 — Fenticonazole
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as diarylthioethers. These are organosulfur compounds containing a thioether group that is substituted by two aryl groups.
Kingdom
Organic compounds
Super Class
Organosulfur compounds
Class
Thioethers
Sub Class
Aryl thioethers
Direct Parent
Diarylthioethers
Alternative Parents
Benzylethers / Thiophenol ethers / Dichlorobenzenes / N-substituted imidazoles / Aryl chlorides / Heteroaromatic compounds / Sulfenyl compounds / Dialkyl ethers / Azacyclic compounds / Organopnictogen compounds
show 3 more
Substituents
1,3-dichlorobenzene / Aromatic heteromonocyclic compound / Aryl chloride / Aryl halide / Azacycle / Azole / Benzenoid / Benzylether / Chlorobenzene / Dialkyl ether
show 18 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
aryl sulfide, imidazoles, ether, dichlorobenzene (CHEBI:83602)
Affected organisms
Not Available

Chemical Identifiers

UNII
QG05NRB077
CAS number
72479-26-6
InChI Key
ZCJYUTQZBAIHBS-UHFFFAOYSA-N
InChI
InChI=1S/C24H20Cl2N2OS/c25-19-8-11-22(23(26)14-19)24(15-28-13-12-27-17-28)29-16-18-6-9-21(10-7-18)30-20-4-2-1-3-5-20/h1-14,17,24H,15-16H2
IUPAC Name
1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)phenyl]methoxy}ethyl]-1H-imidazole
SMILES
ClC1=CC(Cl)=C(C=C1)C(CN1C=CN=C1)OCC1=CC=C(SC2=CC=CC=C2)C=C1

References

General References
  1. TITCK Product Information: Jinomed (fenticonazole nitrate) vaginal cream [Link]
  2. TITCK Product Information: Jinomed (fenticonazole nitrate) vaginal ovule [Link]
ChemSpider
46840
RxNav
24876
ChEBI
83602
ChEMBL
CHEMBL1651990
Wikipedia
Fenticonazole

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentBacterial Vaginosis (BV) / Mixed Vaginal Infections / Vaginal Candidiasis / Vaginitis Trichomonal1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CreamVaginal2 %
CapsuleVaginal
CreamVaginal
SolutionVaginal
SprayCutaneous
SuppositoryVaginal600 mg
SuppositoryVaginal
Aerosol, foamTopical
GelTopical
PowderTopical
ShampooTopical
SolutionTopical
CreamTopical2 %
InsertVaginal600 mg
InsertVaginal60000000 mg
CapsuleVaginal600 mg
CreamVaginal2 g
LotionTopical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000304 mg/mLALOGPS
logP6.31ALOGPS
logP6.94Chemaxon
logS-6.2ALOGPS
pKa (Strongest Basic)6.77Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area27.05 Å2Chemaxon
Rotatable Bond Count8Chemaxon
Refractivity126.14 m3·mol-1Chemaxon
Polarizability47.63 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-0211900000-ca546860e2dcd830129e
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0uei-4050900000-bb5f0cb281224a564134
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-9400000000-51da7e8084136ec31e75
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-056r-9024700000-92c795a64ab2edfcdd31
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-9200000000-393ea65bc7b1a477055d
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-00r5-7920100000-81f5d70e89368dc489d7
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-194.83487
predicted
DeepCCS 1.0 (2019)
[M+H]+197.19289
predicted
DeepCCS 1.0 (2019)
[M+Na]+203.57552
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:42 / Updated at May 05, 2021 20:31