Lanosterol 14-alpha demethylase

BE0000233ProteinYeastERG11

Sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (PubMed:10393548, PubMed:28258218, PubMed:8647850, PubMed:9559662). It is acted on by 33 drugs in DrugBank.

Gene name
ERG11
UniProtKB entry
P10613Swiss-Prot
Cellular location
Membrane
Residues / weight
528 residues · 60,675 Da
Also known as
1.14.13.70 · 1.14.14.154 · CYP51 · CYPLI · Cytochrome P450 51

Resolves to

Protein
UniProtP10613UniProt nameCP51_CANAL
Gene
NCBI Gene3641571GenBank578119
Pharmacology
KEGGcal:CaO19.922
Drugs

What you can answer from here — as of September 04, 2024

33DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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113+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lanosterol 14-alpha demethylase, how selective are they, and which programs against it are still in active trials?

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