Trifluperidol

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Trifluperidol
Accession Number
DB13552
Description
Not Available
Type
Small Molecule
Groups
Experimental
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Structure
Thumb
Weight
Average: 409.425
Monoisotopic: 409.166491637
Chemical Formula
C22H23F4NO2
Synonyms
Not Available

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Trifluperidol.
AcetophenazineThe risk or severity of adverse effects can be increased when Acetophenazine is combined with Trifluperidol.
AclidiniumTrifluperidol may increase the central nervous system depressant (CNS depressant) activities of Aclidinium.
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Trifluperidol.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Trifluperidol.
AlimemazineThe risk or severity of adverse effects can be increased when Alimemazine is combined with Trifluperidol.
AlmotriptanThe risk or severity of adverse effects can be increased when Almotriptan is combined with Trifluperidol.
AlosetronThe risk or severity of adverse effects can be increased when Alosetron is combined with Trifluperidol.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Trifluperidol.
AlverineThe risk or severity of adverse effects can be increased when Alverine is combined with Trifluperidol.
Additional Data Available
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    Extended Description
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  • Action
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Food Interactions
Not Available

Categories

ATC Codes
N05AD02 — Trifluperidol
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as alkyl-phenylketones. These are aromatic compounds containing a ketone substituted by one alkyl group, and a phenyl group.
Kingdom
Organic compounds
Super Class
Organic oxygen compounds
Class
Organooxygen compounds
Sub Class
Carbonyl compounds
Direct Parent
Alkyl-phenylketones
Alternative Parents
Phenylpiperidines / Phenylbutylamines / Butyrophenones / Trifluoromethylbenzenes / Aryl alkyl ketones / Benzoyl derivatives / Aralkylamines / Fluorobenzenes / Aryl fluorides / Gamma-amino ketones
show 8 more
Substituents
Alcohol / Alkyl fluoride / Alkyl halide / Alkyl-phenylketone / Amine / Aralkylamine / Aromatic heteromonocyclic compound / Aryl alkyl ketone / Aryl fluoride / Aryl halide
show 23 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available

Chemical Identifiers

UNII
R8869Q7R8I
CAS number
749-13-3
InChI Key
GPMXUUPHFNMNDH-UHFFFAOYSA-N
InChI
InChI=1S/C22H23F4NO2/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26/h1,3-4,6-9,15,29H,2,5,10-14H2
IUPAC Name
1-(4-fluorophenyl)-4-{4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl}butan-1-one
SMILES
OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C1=CC(=CC=C1)C(F)(F)F

References

General References
Not Available
ChemSpider
5366
BindingDB
50047016
RxNav
10804
ChEBI
135662
ChEMBL
CHEMBL15023
ZINC
ZINC000000538505
Wikipedia
Trifluperidol

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0178 mg/mLALOGPS
logP3.7ALOGPS
logP3.93ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)13.93ChemAxon
pKa (Strongest Basic)8.02ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area40.54 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity103.76 m3·mol-1ChemAxon
Polarizability40.04 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on June 23, 2017 14:44 / Updated on June 12, 2020 10:53

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