Piperaquine

DB13941ApprovedInvestigationalSmall molecule

Piperaquine is an antimalarial agent first synthesized in the 1960's and used throughout China . Its use declined in the 1980's as piperaquine resistant strains of Plasmodium falciparum appeared and... It has come back into use in combination with the artemisinin derivative DB11638 as part of the combination product Eurartesim.

Chemical structure of Piperaquine
Mechanism
Curator reviewed
Primary indication
For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg.Curator reviewed · 1 structured indication
Formula / weight
C29H32Cl2N6 · 535.52 g/mol (avg)
First approval
European Union, 2021
Brand names
  • Eurartesim

Resolves to

Compound
UNIIA0HV2Q956YCAS4085-31-8ChEMBLCHEMBL303933ChEBI91231
Clinical / RWD
ATCP01BF05ATCP01BF07ATCP01BX02PharmGKBPA166104279
Structure
InChIKeyUCRHFBCYFMIWHC-UHFFFAOYSA-NSMILESClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CCCN2CCN(CC2)C2=CC=NC3=C2C=CC(Cl)=C3)CC1
Targets
Q12809KCNH2
Transporters
P13568MDR1

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
1TransporterSubstrate / inhibitor direction, not just membership
Listed above
615Drug interactionsStructured to mechanism, not free text
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119Clinical trialsPhase, status and sponsor resolved per trial
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1Structured indicationCondition, population, route and combination as fields, not prose
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15Marketed productsAcross 4 countries and 5 labellers
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3ATC codesIncluding every combination product, plus 24 drug categories
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24+ReferencesStructured and connected to the statements they support
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