Multidrug resistance protein 1

BE0009167ProteinPlasmodium falciparum (isolate FC27 / Papua New Guinea)MDR1

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. It is acted on by 3 drugs in DrugBank.

Gene name
MDR1
UniProtKB entry
P13568Swiss-Prot
Cellular location
Membrane
Residues / weight
1,419 residues · 162,251 Da
Also known as
3.6.3.44 · 7.6.2.2 · Chloroquine resistance protein · Multidrug resistance protein

Resolves to

Protein
UniProtP13568UniProt nameMDR_PLAFF
Drugs

What you can answer from here — as of May 03, 2025

3DrugsApproved to experimental, with action, bond type and pharmacological action
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8Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Multidrug resistance protein 1, how selective are they, and which programs against it are still in active trials?

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