Cyclopropane
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Cyclopropane
- DrugBank Accession Number
- DB13984
- Background
Cyclopropane was initially investigated because it was thought to be the toxic element in ethylene. Instead, it turned out to be an excellent anesthetic with very rapid onset and recovery while maintaining stable hemodynamics. Its use was ultimately limited because it was highly explosive.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 42.081
Monoisotopic: 42.046950193 - Chemical Formula
- C3H6
- Synonyms
- Ciclopropano
- Cyclopropan
- Cyclopropane
- Cyclopropanum
- Trimethylene
- Zyklopropan
- External IDs
- HSDB 812
- RC 270
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Cyclopropane. Acetazolamide The risk or severity of CNS depression can be increased when Acetazolamide is combined with Cyclopropane. Acetophenazine The risk or severity of CNS depression can be increased when Acetophenazine is combined with Cyclopropane. Agomelatine The risk or severity of CNS depression can be increased when Agomelatine is combined with Cyclopropane. Alfentanil The risk or severity of CNS depression can be increased when Alfentanil is combined with Cyclopropane. - Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 99TB643425
- CAS number
- 75-19-4
- InChI Key
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N
- InChI
- InChI=1S/C3H6/c1-2-3-1/h1-3H2
- IUPAC Name
- cyclopropane
- SMILES
- C1CC1
References
- General References
- Bokoch MP, Gelb AW: From the journal archives: cyclopropane: induction and recovery with a bang! Can J Anaesth. 2014 Aug;61(8):763-6. doi: 10.1007/s12630-014-0109-x. Epub 2014 Jan 14. [Article]
- External Links
- ChemSpider
- 6111
- ChEBI
- 30365
- ChEMBL
- CHEMBL1796999
- Wikipedia
- Cyclopropane
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 10.1 mg/mL ALOGPS logP 1.56 ALOGPS logP 1.33 Chemaxon logS -0.62 ALOGPS Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 13.8 m3·mol-1 Chemaxon Polarizability 5.51 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 115.81258 predictedDeepCCS 1.0 (2019) [M+H]+ 117.70799 predictedDeepCCS 1.0 (2019) [M+Na]+ 125.34102 predictedDeepCCS 1.0 (2019)
Drug created at January 25, 2018 20:58 / Updated at February 21, 2021 18:54