Potassium channel subfamily K member 2

BE0000210ProteinHumansKCNK2

K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. It is acted on by 12 drugs in DrugBank.

Gene name
KCNK2
UniProtKB entry
O95069Swiss-Prot
Cellular location
Cell membrane
Residues / weight
426 residues · 47,092 Da
Also known as
K2P2.1 · Outward rectifying potassium channel protein TREK-1 · TREK · TREK-1 K(+) channel subunit · TREK1

Resolves to

Protein
UniProtO95069UniProt nameKCNK2_HUMAN
Gene
HGNCHGNC:6277NCBI Gene3776GenBank5712621GeneCardsKCNK2
Pharmacology
IUPHAR/GtoPdb514KEGGhsa:3776
Structure
PDB4TWK
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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20GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Potassium channel subfamily K member 2, how selective are they, and which programs against it are still in active trials?

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