Nigericin

DB14056ExperimentalSmall molecule

A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed).

Mechanism: Pharmacologically active on NACHT, LRR and PYD domains-containing protein 3
Curator reviewed
Formula / weight: C₄₀H₆₈O₁₁ · 724.973 g/mol (avg)
Also known as: Azalomycin M · Helixin C · Polyetherin A
Code names: Antibiotic K 178 · Antibiotic X-464 · BRN 1696755 · X-464

Resolves to

Compound

UNIIRRU6GY95ISCAS28380-24-7ChEMBLCHEMBL405862ChEBI7569KEGGC11609

Clinical / RWD

RxNorm2698110

Structure

InChIKeyDANUORFCFTYTSZ-SJSJOXFOSA-NSMILES

[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]1(C)CC[C@@]([H])(O1)[C@]1(C)C[C@@H](C)[C@]2(O1)O[C@]([H])(C[C@@]1([H])CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C(O)=O)C[C@@H](OC)[C@H]2C)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C

Targets

Q96P20NLRP3

What you can answer from here — as of August 30, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

56Drug interactionsStructured to mechanism, not free text

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Nigericin, and which of those have an active Phase 3 trial?

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