NACHT, LRR and PYD domains-containing protein 3

BE0010347ProteinHumansNLRP3

Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:23582325, PubMed:25686105, PubMed:27929086, PubMed:28656979,... It is acted on by 17 drugs in DrugBank.

Gene name
NLRP3
UniProtKB entry
Q96P20Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
1,036 residues · 118,171 Da
Also known as
3.6.4.- · Angiotensin/vasopressin receptor AII/AVP-like · C1orf7 · Caterpiller protein 1.1 · CIAS1

Resolves to

Protein
UniProtQ96P20UniProt nameNLRP3_HUMAN
Gene
HGNCHGNC:16400NCBI Gene114548GeneCardsNLRP3
Pharmacology
IUPHAR/GtoPdb1770KEGGhsa:114548
Structure
PDB2NAQPDB3QF2PDB6NPY
Drugs

What you can answer from here — as of October 31, 2023

17DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NACHT, LRR and PYD domains-containing protein 3, how selective are they, and which programs against it are still in active trials?

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