ONT-093

DB14069ExperimentalSmall molecule

ONT-093 is an orally bioavailable inhibitor of P-glycoprotein (P-gp). In pre-clinical studies, ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics.

Chemical structure of ONT-093
Mechanism
Curator reviewed
Formula / weight
C32H38N4O · 494.683 g/mol (avg)
Code names
OC 144-093 · ONT-093

Resolves to

Compound
UNIIPK2WD2XC83CAS216227-54-2ChEMBLCHEMBL313113
Structure
InChIKeyRSJCLODJSVZNQA-BQYQJAHWSA-NSMILES[H]\C(COCC)=C(\[H])C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=C(NC(C)C)C=C1)C1=CC=C(NC(C)C)C=C1
Targets
P08183ABCB1
Transporters
P08183ABCB1

What you can answer from here — as of March 06, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
1TransporterSubstrate / inhibitor direction, not just membership
Listed above
164Drug interactionsStructured to mechanism, not free text
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9+ReferencesStructured and connected to the statements they support
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