ATP-dependent translocase ABCB1

BE0001032ProteinHumansABCB1

Translocates phospholipids and drugs across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218, PubMed:35507548). It is acted on by 698 drugs in DrugBank.

Gene name
ABCB1
UniProtKB entry
P08183Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,280 residues · 141,477 Da
Also known as
ATP-binding cassette sub-family B member 1 · MDR1 · Multidrug resistance protein 1 · P-glycoprotein 1 · PGY1

Resolves to

Protein
UniProtP08183UniProt nameMDR1_HUMAN
Gene
HGNCHGNC:40NCBI Gene5243GenBank307180GeneCardsABCB1
Pharmacology
IUPHAR/GtoPdb768KEGGhsa:5243
Structure
PDB6C0VPDB6FN1PDB6FN4
Drugs

What you can answer from here — as of September 03, 2024

698DrugsApproved to experimental, with action, bond type and pharmacological action
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44Clinical trialsTrials of drugs acting on it, by phase and status
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29GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1,645+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-dependent translocase ABCB1, how selective are they, and which programs against it are still in active trials?

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